https://scholars.lib.ntu.edu.tw/handle/123456789/412838
標題: | No association of CYP2E1 genetic polymorphisms with alcohol dependence in Han Taiwanese population | 作者: | Huang, Cho-Yin Kao, Chung-Feng Chen, Chiao-Chicy PO-HSIU KUO HSIU-PO KUO |
關鍵字: | Alcohol dependence; CYP2E1 gene; Haplotype; Single nucleotide polymorphisms; Taiwan | 公開日期: | 七月-2018 | 出版社: | ELSEVIER TAIWAN | 卷: | 117 | 期: | 7 | 起(迄)頁: | 646-649 | 來源出版物: | Journal of the Formosan Medical Association = Taiwan yi zhi | 摘要: | Cytochrome P450 2E1 (CYP2E1) gene is one of the candidate genes for alcohol dependence (AD). Four single nucleotide polymorphisms (SNPs) of CYP2E1 gene (CYP2E1*1D, *5B, *6 and *1B) have been associated with AD previously in other ethnic populations. To date, only CYP2E1*5B and *6 SNPs have been investigated in relation to AD in our population. The objective of the study was to examine the genetic associations of CYP2E1 covering the four above-noted SNPs conjointly with AD in Han Taiwanese population based on single SNP analysis and haplotype-based approach. We enrolled a total of 340 patients fulfilling DSM-IV-TR diagnostic criteria of AD and 319 healthy controls and genotyped them for the above four SNPs of CYP2E1 gene. By comparing the differences of genotype, allele, and pertinent haplotype frequencies, we did not support a genetic association between CYP2E1 and AD in Han Taiwanese either by single allele tests or haplotype-based analyses. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/412838 | ISSN: | 0929-6646 | DOI: | https://api.elsevier.com/content/abstract/scopus_id/85044278864 10.1016/j.jfma.2018.03.007 |
SDG/關鍵字: | cytochrome P450 2E1; cytochrome P450 2E1; adult; aged; alcoholism; allele; Article; controlled study; DSM-IV-TR; female; gene frequency; genetic association; genotype; haplotype; human; major clinical study; male; single nucleotide polymorphism; Taiwanese; alcoholism; Asian continental ancestry group; case control study; genetics; middle aged; statistical model; Taiwan; Adult; Alcoholism; Alleles; Asian Continental Ancestry Group; Case-Control Studies; Cytochrome P-450 CYP2E1; Female; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Polymorphism, Single Nucleotide; Taiwan |
顯示於: | 流行病學與預防醫學研究所 |
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