https://scholars.lib.ntu.edu.tw/handle/123456789/413476
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YI-SHUAN SHEEN | en_US |
dc.contributor.author | YI-HUA LIAO | en_US |
dc.contributor.author | HSIEN-CHING CHIU | en_US |
dc.contributor.author | SHIOU-HWA JEE | en_US |
dc.contributor.author | CHIA-YU CHU | en_US |
dc.contributor.author | Hsieh M.-C. | en_US |
dc.contributor.author | Chen P.-C. | en_US |
dc.contributor.author | Cha S.-T. | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | Chang C.-C. | en_US |
dc.contributor.author | Jee S.-H. | en_US |
dc.contributor.author | Kuo M.-L. | en_US |
dc.contributor.author | CHIA-YING CHU | en_US |
dc.creator | Yi-Shuan Sheen;Yi-Hua Liao;Hsien-Ching Chiu;Shiou-Hwa Jee;Chia-Yu Chu | - |
dc.date.accessioned | 2019-07-11T06:59:24Z | - |
dc.date.available | 2019-07-11T06:59:24Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/413476 | - |
dc.description.abstract | IGF II mRNA-binding protein 3 (IMP-3) has been reported to be a marker of melanoma progression. However, the mechanisms by which it impacts melanoma are incompletely understood. In this study, we investigate the clinical significance of IMP-3 in melanoma progression and also its underlying mechanisms. We found that IMP-3 expression was much higher in advanced-stage/metastatic melanomas and that it was associated with a poor prognosis (P=0.001). Univariate analysis showed that IMP-3 expression was associated with stage III/IV melanomas (odds ratio=5.40, P=0.031) and the acral lentiginous subtype (odds ratio=3.93, P=0.0034). MeWo cells with overexpression of IMP-3 showed enhanced proliferation and migration and significantly increased tumorigenesis and metastatic ability in nude mice. We further demonstrated that IMP-3 could bind and enhance the stability of the mRNA of high mobility group AT-hook 2 (HMGA2). It was also confirmed that IMP-3 had an important role in melanoma invasion and metastasis through regulating HMGA2 mRNA expression. IMP-3 expression was positively correlated with HMGA2 expression in melanoma cells and also in melanoma tissues. Our results show that IMP-3 expression is a strong prognostic factor for melanoma, especially acral lentiginous melanoma. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.relation.ispartof | The Journal of investigative dermatology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | high mobility group A2 protein; messenger RNA; tissue inhibitor of metalloproteinase 3; high mobility group A2 protein; IMP3 protein, human; RNA binding protein; tumor marker; acral lentiginous melanoma; aged; animal cell; animal tissue; Article; cancer growth; cancer patient; cancer prognosis; cell invasion; cell migration; cell proliferation; controlled study; correlational study; female; follow up; gene overexpression; human; investigative procedures; major clinical study; male; melanoma; melanoma cell; metastatic melanoma; mouse; nonhuman; priority journal; protein expression; cell motion; disease course; DNA microarray; gene expression regulation; melanoma; metabolism; metastasis; prognosis; risk; skin tumor; tumor cell line; tumor invasion; Cell Line, Tumor; Cell Movement; Disease Progression; Gene Expression Regulation, Neoplastic; HMGA2 Protein; Humans; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Odds Ratio; Oligonucleotide Array Sequence Analysis; Prognosis; RNA-Binding Proteins; Skin Neoplasms; Tumor Markers, Biological | - |
dc.title | IMP-3 promotes migration and invasion of melanoma cells by modulating the expression of HMGA2 and predicts poor prognosis in melanoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | https://api.elsevier.com/content/abstract/scopus_id/84925455121 | - |
dc.identifier.doi | 10.1038/jid.2014.480 | - |
dc.identifier.pmid | 25380351 | - |
dc.identifier.scopus | 2-s2.0-84925455121 | - |
dc.identifier.isi | WOS:000351188600022 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84925455121 | - |
dc.relation.pages | 1065 | en_US |
dc.relation.journalvolume | 135 | en_US |
dc.relation.journalissue | 4 | en_US |
dc.relation.pageend | 1073 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.orcid | 0000-0002-8743-7496 | - |
crisitem.author.orcid | 0000-0002-4434-3780 | - |
crisitem.author.orcid | 0000-0002-1409-8470 | - |
crisitem.author.orcid | 0000-0001-6737-6297 | - |
crisitem.author.orcid | 0000-0002-9370-3279 | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.orcid | 0000-0003-1619-1975 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 醫學系 |
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