https://scholars.lib.ntu.edu.tw/handle/123456789/413594
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Sheen L.-Y. | en_US |
dc.contributor.author | Chen H.-W. | en_US |
dc.contributor.author | Kung Y.-L. | en_US |
dc.contributor.author | Liu C.-T. | en_US |
dc.contributor.author | Lii C.-K. | en_US |
dc.creator | Sheen L.-Y.; Chen H.-W.; Kung Y.-L.; Liu C.-T.; Lii C.-K. | - |
dc.date.accessioned | 2019-07-11T09:16:48Z | - |
dc.date.available | 2019-07-11T09:16:48Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1635581 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/413594 | - |
dc.description.abstract | We examined the effects of garlic oil (GO) and two of its organosulfur compounds, diallyl sulfide (DAS) and diallyl disulfide (DADS), on the drug- metabolizing and antioxidant systems in rats and sought to determine whether these effects are associated with dietary fat. Rats were fed a high-fat diet and received GO or DADS (200 mg/kg body wt) or DAS (100 mg/kg) orally three times a week for seven weeks. Control animals received corn oil alone. Another group of rats was fed a low-fat diet, with or without GO. GO and DADS significantly reduced the body weight gain of rats (p <0.05). GO, however, dramatically increased the spleen weight and spleen weight-to-body weight ratio (p < 0.05). DAS increased glutathione S-transferase (GST) and 7- pentoxyresorufin O-dealkylase activities, whereas DADS increased only GST activity (p<0.05). Immunoblot assay showed GO-, DAS-, and DADS-enhanced expression of the placental form of GST and cytochrome P-450 IIBI but suppressed cytochrome P-450 IIEI expression. Hepatic antioxidant enzyme activities were also modulated by these garlic components. GO and DADS inhibited glutathione peroxidase activity (p<0.05), and DADS and DAS enhanced glutathione reductase activity (p<0.05). Only GO enhanced the superoxide dismutase activity (p<0.05). All these garlic components increased glutathione levels in red blood cells (p<0.05) but did not influence hepatic glutathione levels. Although the amount of fat in the diet modulated drug- metabolizing and antioxidant functions, no interactions between GO and dietary fat were observed. These results indicate that GO and its allyl sulfide components, as well as dietary lipid, modulate drug-metabolizing and antioxidant enzyme activities. The action of GO appears to be independent of dietary lipid content. | - |
dc.language | English | - |
dc.relation.ispartof | Nutrition and Cancer | - |
dc.title | Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes in rats fed high- and low-fat diets | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1207/S15327914NC352_10 | - |
dc.identifier.scopus | 2-s2.0-0033500043 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033500043&doi=10.1207%2fS15327914NC352_10&partnerID=40&md5=0a956af626d46c6f78c25f15e309d29d | - |
dc.relation.pages | 160-166 | - |
dc.relation.journalvolume | 35 | - |
dc.relation.journalissue | 2 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0001-5541-652X | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所 |
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