https://scholars.lib.ntu.edu.tw/handle/123456789/413696
標題: | Improving biocompatibility by surface modification techniques on implantable bioelectronics | 作者: | Lin P. Lin C.-W. Mansour R. Gu F. |
關鍵字: | Biocompatibility; Implantable bioelectronics; Nano-texture; Non-fouling; Protein adsorption; Zwitterionic | 公開日期: | 2013 | 卷: | 47 | 起(迄)頁: | 451-460 | 來源出版物: | Biosensors and Bioelectronics | 摘要: | For implantable bioelectronic devices, the interface between the device and the biological environment requires significant attention as it dictates the device performance in vivo. Non-specific protein adsorption onto the device surface is the initial stage of many degradation mechanisms that will ultimately compromise the functionality of the device. In order to preserve the functionality of any implanted bioelectronics overtime, protein adsorption must be controlled. This review paper outlines two major approaches to minimize protein adsorption onto the surface of implantable electronics. The first approach is surface coating, which minimizes close proximity interactions between proteins and device surfaces by immobilizing electrically neutral hydrophilic polymers as surface coating. These coatings reduce protein fouling by steric repulsion and formation of a hydration layer which acts as both a physical and energetic barrier that minimize protein adsorption onto the device. Relevant performances of various conventional hydrophilic coatings are discussed. The second approach is surface patterning using arrays of hydrophobic nanostructures through photolithography techniques. By establishing a large slip length via super hydrophobic surfaces, the amount of proteins adsorbed to the surface of the device can be reduced. The last section discusses emerging surface coating techniques utilizing zwitterionic polymers where ultralow-biofouling surfaces have been demonstrated. These surface modification techniques may significantly improve the long-term functionality of implantable bioelectronics, thus allowing researchers to overcome challenges to diagnose and treat chronic neurological and cardiovascular diseases. ? 2013 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877120324&doi=10.1016%2fj.bios.2013.01.071&partnerID=40&md5=3cc39b64070efb23ae25cb308dfd5f68 https://scholars.lib.ntu.edu.tw/handle/123456789/413696 |
ISSN: | 9565663 | DOI: | 10.1016/j.bios.2013.01.071 | SDG/關鍵字: | Implantable bioelectronics; Nano-texture; Nonfouling; Protein adsorption; Zwitterionic; Biocompatibility; Degradation; Hydrophilicity; Hydrophobicity; Nanostructures; Photolithography; Plastic coatings; Proteins; Surface chemistry; Polymers; macrogol; biocompatibility; device safety; electronics; hydrophilicity; implantable bioelectronics; material coating; physical chemistry; polymerization; process optimization; protein adsorption; protein analysis; protein immobilization; protein interaction; protein modification; protein targeting; review; surface property; Adsorption; Biofouling; Bioprosthesis; Humans; Hydrophobic and Hydrophilic Interactions; Polymers; Proteins; Surface Properties |
顯示於: | 醫學工程學研究所 |
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