DC 欄位 | 值 | 語言 |
dc.contributor.author | Yang L.-C. | en_US |
dc.contributor.author | Lu T.-J. | en_US |
dc.contributor.author | Lin W.-C. | en_US |
dc.creator | Lin W.-C.;Lu T.-J.;Yang L.-C. | - |
dc.date.accessioned | 2019-07-16T08:48:50Z | - |
dc.date.available | 2019-07-16T08:48:50Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1741427X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/414033 | - |
dc.description.abstract | Anoectochilus formosanus is an herb well known in Asian countries. The polysaccharide isolated from A. formosanus consists of type II arabinogalactan (AGAF), with branched 3,6-Gal as the major moiety. In this study, AGAF was examined for the granulocyte colony-stimulating factor (G-CSF) production and related protein expression in RAW 264.7 murine macrophages. The signaling pathway of G-CSF production involves AGAF and mitogen-activated protein kinases (MAPKs) inhibitors and pattern-recognition receptor antibodies. AGAF was evaluated to ease the leukopenia in CT26-colon-cancer-bearing mice treated with 5-fluorouracil (5-FU). The results of this study showed that AGAF was a stimulant for Toll-like receptor 2 and Dectin-1 and that it induced G-CSF production, through p38 and ERK MAPK, and NF-B pathways. In vivo examination showed that the oral administration of AGAF mitigated the side effects of leukopenia caused by 5-FU in colon-cancer-bearing mice. In conclusion, the botanic type II AGAF in this study was a potent G-CSF inducer in vivo and in vitro. ? 2013 Li-Chan Yang et al. | en_US |
dc.language | English | - |
dc.relation.ispartof | Evidence-based Complementary and Alternative Medicine | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | arabinogalactan; dectin 1; fluorouracil; granulocyte colony stimulating factor; mitogen activated protein kinase; pattern recognition receptor; toll like receptor 2; animal cell; animal experiment; animal model; Anoectochilus formosanus; article; cell viability; colon cancer; comparative study; controlled study; cytokine production; enzyme phosphorylation; herb; leukocyte; leukocyte count; leukopenia; macrophage; male; mouse; nonhuman; priority journal; protein expression; spleen weight; Western blotting | - |
dc.title | A type II arabinogalactan from anoectochilus formosanus for G-CSF production in macrophages and leukopenia improvement in CT26-bearing mice treated with 5-fluorouracil | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1155/2013/458075 | - |
dc.identifier.doi | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885439360&doi=10.1155%2f2013%2f458075&partnerID=40&md5=186919fe4544361af980588bdf454524 | - |
dc.identifier.scopus | 2-s2.0-84885439360 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885439360&doi=10.1155%2f2013%2f458075&partnerID=40&md5=186919fe4544361af980588bdf454524 | - |
dc.relation.journalvolume | 2013 | en_US |
item.openairetype | journal article | - |
item.fulltext | with fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0002-3956-8272 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所
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