https://scholars.lib.ntu.edu.tw/handle/123456789/414036
標題: | Cembrane derivatives from the soft corals, Sinularia gaweli and Sinularia flexibilis | 作者: | Hu L.-C. Yen W.-H. Su J.-H. Chiang M.Y.-N. Wen Z.-H. Chen W.-F. Lu T.-J. Chang Y.-W. Chen Y.-H. Wang W.-H. Wu Y.-C. Sung P.-J. |
關鍵字: | Anti-inflammatory activity;Cembrane;Norcembrane;Sinularia flexibilis;Sinularia gaweli;X-ray | 公開日期: | 2013 | 卷: | 11 | 期: | 6 | 起(迄)頁: | 2154-2167 | 來源出版物: | Marine Drugs | 摘要: | A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. ? 2013 by the authors; licensee MDPI. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/414036 | ISSN: | 16603397 | DOI: | 10.3390/md11062154 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879497299&doi=10.3390%2fmd11062154&partnerID=40&md5=c6b63dd1b4fd71a4618a36f753ff22ab |
顯示於: | 食品科技研究所 |
檔案 | 描述 | 大小 | 格式 | |
---|---|---|---|---|
marinedrugs-11-02154.pdf | 738.66 kB | Adobe PDF | 檢視/開啟 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。