https://scholars.lib.ntu.edu.tw/handle/123456789/414080
Title: | Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression | Authors: | Ting Y. Chang W.-T. Shiau D.-K. Chou P.-H. Wu M.-F. Hsu C.-L. |
Keywords: | high-fat diet;litchi flower extract;lycopene;quercetin;taurine | Issue Date: | 2018 | Journal Volume: | 66 | Journal Issue: | 1 | Start page/Pages: | 70-80 | Source: | Journal of Agricultural and Food Chemistry | Abstract: | The antiobesity effects of quercetin-rich supplement (QRS), which contain quercetin, lycopene, taurine, and litchi flower extract, on a high-fat diet (HFD)-induced obese rats were investigated. The rats that consume HFD with QRS (185 mg/kg rat) have significantly modulated the final body weights [490 ¡Ó 11 (HFD) ¡÷ 441 ¡Ó 11 (HFD+QRS) g], total body fat [112.9 ¡Ó 4.5 (HFD) ¡÷ 86.6 ¡Ó 5.7 (HFD+QRS) g], liver weights [14.8 ¡Ó 0.4 (HFD) ¡÷ 12.6 ¡Ó 0.4 (HFD+QRS) g/rat], and the serum TG [102.5 ¡Ó 7.3 (HFD) ¡÷ 90.7 ¡Ó 6.5 (HFD+QRS) mg/dL] to a level that resembled the regular diet-consumed rats (p < 0.05). The excretion of lipid in the faeces augmented in QRS groups as compared with the nonsupplemented HFD group [faecal total lipid: 62.43 ¡Ó 2.80 (HFD) ¡÷ 73.15 ¡Ó 0.88 (HFD+QRS) mg/g dried faeces, p < 0.05]. In the histological analysis, quercetin-rich formulation supplemented groups presented a much less lipid accumulation and smaller size of adipocytes. Moreover, a decreased serum thiobarbituric acid reactive substances [1.55 ¡Ó 0.17 (HFD) ¡÷ 0.78 ¡Ó 0.04 (HFD+QRS) nmol MDA eq/mL serum] increased levels of serum Trolox equivalent antioxidant capacity [3.89 ¡Ó 0.08 (HFD) ¡÷ 6.46 ¡Ó 0.20 (HFD+QRS) £gmol/mL serum], and more active hepatic antioxidant enzymes were observed in the supplemented groups (p < 0.05). The result of this work is a good demonstration of how a combination of bioactive compounds could work synergistically and become very effective in disease prevention. ? 2017 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/414080 | ISSN: | 00218561 | DOI: | 10.1021/acs.jafc.7b03551 | SDG/Keyword: | Amino acids; Antioxidants; Biochemistry; Flavonoids; Gene expression; Phenols; Rats; Flower extracts; High-fat diet; Lycopenes; quercetin; taurine; Body fluids; antiobesity agent; lipid; quercetin; adipose tissue; animal; blood; body composition; body weight; dietary supplement; drug effects; gene expression regulation; genetics; lipid diet; lipid metabolism; male; obesity; organ size; oxidative stress; Wistar rat; Adipose Tissue; Animals; Anti-Obesity Agents; Body Composition; Body Weight; Diet, High-Fat; Dietary Supplements; Gene Expression Regulation; Lipid Metabolism; Lipids; Male; Obesity; Organ Size; Oxidative Stress; Quercetin; Rats, Wistar |
Appears in Collections: | 食品科技研究所 |
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