DC 欄位 | 值 | 語言 |
dc.contributor.author | Luo M. | en_US |
dc.contributor.author | Tai R. | en_US |
dc.contributor.author | CHUN-WEI YU | en_US |
dc.contributor.author | Yang S. | en_US |
dc.contributor.author | Chen C.-Y. | en_US |
dc.contributor.author | Lin W.-D. | en_US |
dc.contributor.author | Schmidt W. | en_US |
dc.contributor.author | KEQIANG WU | en_US |
dc.creator | Wu K.;Schmidt W.;Lin W.-D.;Chen C.-Y.;Yang S.;Yu C.-W.;Tai R.;Luo M. | - |
dc.date.accessioned | 2019-07-17T04:20:36Z | - |
dc.date.available | 2019-07-17T04:20:36Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 09607412 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/414195 | - |
dc.description.abstract | Summary The acetylation level of histones on lysine residues regulated by histone acetyltransferases and histone deacetylases plays an important but under-studied role in the control of gene expression in plants. With the aim of characterizing the Arabidopsis RPD3/HDA1 family histone deacetylase HDA5, we present evidence showing that HDA5 displays deacetylase activity. Mutants defective in the expression of HDA5 displayed a late-flowering phenotype. Expression of the flowering repressor genes FLC and MAF1 was up-regulated in hda5 mutants. Furthermore, the gene activation markers, histone H3 acetylation and H3K4 trimethylation on FLC and MAF1 chromatin were increased in hda5-1 mutants. Chromatin immunoprecipitation analysis showed that HDA5 binds to the chromatin of FLC and MAF1. Bimolecular fluorescence complementation assays and co-immunoprecipitation assays showed that HDA5 interacts with FVE, FLD and HDA6, indicating that these proteins are present in a protein complex involved in the regulation of flowering time. Comparing gene expression profiles of hda5 and hda6 mutants by RNA-seq revealed that HDA5 and HDA6 co-regulate gene expression in multiple development processes and pathways. Significance Statement We found that HISTONE DEACETYLASE 5 (HDA5) and HDA6 form a HDAC repression complex with FVE and FLD involved in the regulation of flowering time in Arabidopsis. ? 2015 The Authors. | en_US |
dc.language | English | - |
dc.relation.ispartof | Plant Journal | en_US |
dc.subject | Arabidopsis | en_US |
dc.subject | flowering | en_US |
dc.subject | HDA5 | en_US |
dc.subject | HDA6 | en_US |
dc.subject | histone deacetylase | en_US |
dc.title | Regulation of flowering time by the histone deacetylase HDA5 in Arabidopsis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/tpj.12868 | - |
dc.identifier.doi | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930872883&doi=10.1111%2ftpj.12868&partnerID=40&md5=e5c780e342aa258ca03dc9b6761849ee | - |
dc.identifier.scopus | 2-s2.0-84930872883 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930872883&doi=10.1111%2ftpj.12868&partnerID=40&md5=e5c780e342aa258ca03dc9b6761849ee | - |
dc.relation.pages | 925-936 | en_US |
dc.relation.journalvolume | 82 | en_US |
dc.relation.journalissue | 6 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
crisitem.author.dept | Molecular and Cellular Biology | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Plant Biology | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Ph. D. Program In Plant Biotechnology Development Of Industry-academia Cooperation | - |
crisitem.author.orcid | 0000-0003-1475-5247 | - |
crisitem.author.orcid | 0000-0002-5791-3594 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 植物科學研究所
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