https://scholars.lib.ntu.edu.tw/handle/123456789/414225
標題: | Fine-Tuning of Type I Interferon Response by STAT3 | 作者: | Tsai, Ming-Hsun Pai, Li-Mei CHIEN-KUO LEE |
關鍵字: | SOCS3; STAT3; antiviral immunity; phospholipid scramblase 2; type I interferon (IFN-I) | 公開日期: | 六月-2019 | 出版社: | FRONTIERS MEDIA SA | 卷: | 10 | 起(迄)頁: | 1448 | 來源出版物: | Frontiers in immunology | 摘要: | Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation. STAT1, STAT2, and IRF9 form ISGF3 complex which transactivates downstream IFN-stimulated genes and mediates antiviral response. However, the role of STAT3 remains to be characterized. Here, we review the multiple actions of STAT3 on suppressing IFN-I responses, including blocking IFN-I signaling, downregulating the expression of ISGF3 components, and antagonizing the transcriptional activity of ISGF3. Finally, we discuss the evolution of the suppressive activity of STAT3 and the therapeutic potential of STAT3 inhibitors in host defense against viral infections and IFN-I-associated diseases. |
URI: | https://www.ncbi.nlm.nih.gov/pubmed/31293595 https://scholars.lib.ntu.edu.tw/handle/123456789/414225 |
ISSN: | 1664-3224 |
顯示於: | 免疫學研究所 |
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