https://scholars.lib.ntu.edu.tw/handle/123456789/415320
標題: | Intracranial aneurysms formation after radiotherapy for head and neck cancer: A 10-year nationwide follow-up study | 作者: | HSIAO-YU YANG Pau-Chung CHEN PAU-CHUNG CHEN Wang T.-C. Chen K.-J. Cheng C.-Y. Lai C.-H. |
關鍵字: | Aneurysm; Head and neck cancer; Radiotherapy; Vasculopathy | 公開日期: | 2019 | 出版社: | BioMed Central Ltd. | 卷: | 19 | 期: | 1 | 來源出版物: | BMC Cancer | 摘要: | Background: Intracranial aneurysms after radiotherapy (RT) have previously been reported. However, the majority of studies were case reports. Therefore, we performed a nationwide study to explore the risk of radiation-induced intracranial aneurysms. Methods: This study included patients diagnosed with head and neck cancer (ICD9: 140-149, 161). Intracranial aneurysms formation was identified using the following ICD9 codes: nonruptured cerebral aneurysm (ICD9:4373), aneurysm clipping (ICD9:3951). Patients who did not receive curative treatment and those with intracranial aneurysms before the diagnosis of head and neck cancer were excluded. Results: In total, 70,691 patients were included in the final analysis; they were categorized into the following three groups: nasopharyngeal carcinoma (NPC) with RT, non-NPC with RT, and non-NPC without RT. Patients in the NPC with RT group had the highest risk of developing intracranial aneurysms (hazard ratio (HR) 2.57; P < 0.001). In addition, hypertension was also a risk factor of developing intracranial aneurysms (HR 2.14; P < 0.01). The mean time interval from cancer diagnosis to intracranial aneurysm formation in the NPC with RT group was 4.3 ± 3.1 years. Conclusions: Compared with the non-NPC with RT and the non-NPC without RT groups, patients with NPC who received RT had a higher risk of developing intracranial aneurysms. ? 2019 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066822050&doi=10.1186%2fs12885-019-5766-2&partnerID=40&md5=8be80c28b0ff77c035c5b8ea87e8e2fb https://scholars.lib.ntu.edu.tw/handle/123456789/415320 |
ISSN: | 14712407 | DOI: | 10.1186/s12885-019-5766-2 | SDG/關鍵字: | adult; aged; aneurysm clipping; Article; cancer diagnosis; cancer radiotherapy; cancer risk; clinical evaluation; clinical feature; controlled study; disease course; female; follow up; head and neck cancer; high risk patient; human; hypertension; ICD-9; intracranial aneurysm; major clinical study; male; nasopharynx carcinoma; radiation hazard; risk assessment; risk factor; adverse event; complication; incidence; intracranial aneurysm; Kaplan Meier method; middle aged; proportional hazards model; radiation dose; sex factor; Taiwan; Adult; Aged; Female; Follow-Up Studies; Humans; Hypertension; Incidence; Intracranial Aneurysm; Kaplan-Meier Estimate; Male; Middle Aged; Nasopharyngeal Carcinoma; Proportional Hazards Models; Radiation Dosage; Radiotherapy; Risk Factors; Sex Factors; Taiwan |
顯示於: | 環境與職業健康科學研究所 |
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