https://scholars.lib.ntu.edu.tw/handle/123456789/415784
標題: | Prediction of pneumoconiosis by serum and urinary biomarkers in workers exposed to asbestos-contaminated minerals | 作者: | HSIAO-YU YANG | 公開日期: | 2019 | 出版社: | Public Library of Science | 卷: | 14 | 期: | 4 | 來源出版物: | PLoS ONE | 摘要: | Workers processing nephrite, antigorite, or talc may be exposed to paragenetic asbestos minerals. An effective screening method for pneumoconiosis in workers exposed to asbestos-contaminated minerals is still lacking. The objective of this study was to assess the diagnostic accuracy of serum and urinary biomarkers for pneumoconiosis in workers exposed to asbestos-contaminated minerals. We conducted a case-control study in a cohort of stone craft workers in Hualien, where asbestos, nephrite, antigorite, and talc are produced. A total of 140 subjects were screened between March 2013 and July 2014. All subjects received a questionnaire survey and a health examination that included a physical examination; chest X-ray; and tests for standard pulmonary function, fractional exhaled nitric oxide, serum soluble mesothelin-related peptide (SMRP), fibulin-3, carcinoembryonic antigen (CEA), and urinary 8-Oxo-2’-deoxyguanosine (8-OHdG)/creatinine. After excluding subjects with uraemia and chronic obstructive pulmonary disease (COPD), we included 48 subjects with pneumoconiosis and 90 control subjects without pneumoconiosis for analysis. In terms of occupational history, 43/48 (90%) case subjects and 68% (61/90) of the control subjects had processed asbestos-contaminated minerals, including nephrite, antigorite, and talc. The case group had decreased pulmonary function in forced vital capacity (FVC), forced expiratory volume in one second, and forced expiratory flow between 25% and 75% of the FVC. The levels of SMRP, fibulin-3, urinary 8-OHdG/creatinine, and CEA were higher in the case group than in the control group. Subjects exposed to nephrite had significantly higher SMRP levels (0.84 ± 0.52 nM) than subjects exposed to other types of minerals (0.60 ± 0.30 nM). A dose-response relationship was observed between the SMRP level and the severity of pneumoconiosis. Machine learning algorithms, including variables of sex, age, SMRP, fibu-lin-3, CEA, and 8-OHdG/creatinine, can predict pneumoconiosis with high accuracy. The areas under the receiver operating characteristic curves ranged from 0.7 to 1.0. We suggest that SMRP and fibulin-3 could be used as biomarkers of pneumoconiosis in workers exposed to asbestos-contaminated minerals. ? 2019 Hsiao-Yu Yang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063968004&doi=10.1371%2fjournal.pone.0214808&partnerID=40&md5=908ab51dacc1b1a3ffd86d5916b129f7 https://scholars.lib.ntu.edu.tw/handle/123456789/415784 |
ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0214808 | SDG/關鍵字: | 8 hydroxydeoxyguanosine; antigorite; asbestos; biological marker; carcinoembryonic antigen; creatinine; fibulin; fibulin 3; mesothelin; mineral; nephrite; serum soluble mesothelin related peptide; talc; unclassified drug; asbestos; biological marker; carcinoembryonic antigen; chrysotile; creatinine; EFEMP1 protein, human; glycosylphosphatidylinositol anchored protein; mesothelin; mineral; scleroprotein; talc; adult; Article; case control study; clinical article; cohort analysis; controlled study; diagnostic accuracy; disease severity; female; forced expiratory flow; forced expiratory volume; forced vital capacity; fractional exhaled nitric oxide; human; industrial worker; lung function test; machine learning; male; occupational exposure; physical examination; pneumoconiosis; prediction; receiver operating characteristic; thorax radiography; adverse event; aged; asbestosis; blood; maximal mid expiratory flow; middle aged; pathophysiology; pneumoconiosis; Taiwan; urine; vital capacity; 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Asbestos; Asbestos, Serpentine; Asbestosis; Biomarkers; Carcinoembryonic Antigen; Case-Control Studies; Cohort Studies; Creatinine; Extracellular Matrix Proteins; Female; Forced Expiratory Volume; GPI-Linked Proteins; Humans; Male; Maximal Midexpiratory Flow Rate; Middle Aged; Minerals; Occupational Exposure; Pneumoconiosis; Taiwan; Talc; Vital Capacity |
顯示於: | 環境與職業健康科學研究所 |
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