|Title:||Metabolomics of Children and Adolescents Exposed to Industrial Carcinogenic Pollutants||Authors:||Chi-Hsin Sally Chen
Tseng, Yufeng J
YUFENG JANE TSENG
|Issue Date:||7-May-2019||Publisher:||AMER CHEMICAL SOC||Journal Volume:||53||Journal Issue:||9||Start page/Pages:||5454-5465||Source:||Environmental science & technology||Abstract:||
Studies on metabolomes of carcinogenic pollutants among children and adolescents are limited. We aim to identify metabolic perturbations in 107 children and adolescents (aged 9-15) exposed to multiple carcinogens in a polluted area surrounding the largest petrochemical complex in Taiwan. We measured urinary concentrations of eight carcinogen exposure biomarkers (heavy metals and polycyclic aromatic hydrocarbons (PAHs) represented by 1-hydroxypyrene), and urinary oxidative stress biomarkers and serum acylcarnitines as biomarkers of early health effects. Serum metabolomics was analyzed using a liquid chromatography mass spectrometry-based method. Pathway analysis and "meet-in-the-middle" approach were applied to identify potential metabolites and biological mechanisms linking carcinogens exposure with early health effects. We found 10 potential metabolites possibly linking increased exposure to IARC group 1 carcinogens (As, Cd, Cr, Ni) and group 2 carcinogens (V, Hg, PAHs) with elevated oxidative stress and deregulated serum acylcarnitines, including inosine monophosphate and adenosine monophosphate (purine metabolism), malic acid and oxoglutaric acid (citrate cycle), carnitine (fatty acid metabolism), and pyroglutamic acid (glutathione metabolism). Purine metabolism was identified as the possible mechanism affected by children and adolescents' exposure to carcinogens. These findings contribute to understanding the health effects of childhood and adolescence exposure to multiple industrial carcinogens during critical periods of development.
Biomarkers; Body fluids; Fatty acids; Health; Heavy metals; Liquid chromatography; Mass spectrometry; Metabolism; Metabolites; Pollution; Polycyclic aromatic hydrocarbons; Adenosine monophosphate; Biological mechanisms; Children and adolescents; Glutathione metabolism; Liquid chromatography - mass spectrometries; Oxidative stress biomarkers; Petrochemical complex; Polycyclic aromatic hydrocarbons (PAHS); Carcinogens; 2 oxoglutaric acid; 2 oxoisocaproic acid; adenosine phosphate; arsenic; aspartic acid; cadmium; carcinogen; carnitine; chromium; inosine phosphate; isovalerylcarnitine; malic acid; mercury; nickel; polycyclic aromatic hydrocarbon; pyroglutamic acid; unclassified drug; vanadium; biological marker; carcinogen; polycyclic aromatic hydrocarbon; adolescence; carcinogen; child health; health impact; industrial emission; metabolism; oxidative stress; PAH; pollution effect; pollution exposure; serum; adolescent; Article; body mass; comparative study; controlled study; down regulation; environmental exposure; female; high performance liquid chromatography; human; kidney concentrating capacity; lipid peroxidation; liquid chromatography-mass spectrometry; major clinical study; male; metabolomics; method detection limit; oxidative stress; partial least squares regression; pollutant; purine metabolism; quality control; quantitative analysis; systolic blood pressure; urine level; child; environmental monitoring; metabolomics; Taiwan; Taiwan; Adolescent; Biomarkers; Carcinogens; Child; Environmental Monitoring; Environmental Pollutants; Humans; Metabolomics; Polycyclic Aromatic Hydrocarbons; Taiwan
|Appears in Collections:||環境與職業健康科學研究所|
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