https://scholars.lib.ntu.edu.tw/handle/123456789/415888
標題: | Nano-lipospheres as acoustically active ultrasound contrast agents: Evolving tumor imaging and therapy technique | 作者: | Andrews, L.E. Chan, M.-H. Liu, R.-S. |
關鍵字: | active targeting; drug delivery; nanobubbles; theranostic; ultrasonography | 公開日期: | 2019 | 卷: | 30 | 期: | 18 | 起(迄)頁: | 182001 | 來源出版物: | Nanotechnology | 摘要: | Applying nanobubbles (NBs) for contrast-enhanced ultrasound imaging has received increased attention. NBs are biocompatible, multifunctional, theranostic agents. Their properties of high echogenicity and stability create an agent suitable for ultrasonography diagnosis. Their favorable properties of size, in vivo stability, and ease of modification are being exploited to implement a theranostic platform for cancer treatment. The considerable development offers the potential to overcome drug resistance and adverse side effects that are associated with traditional chemotherapy. This review outlines the principles of ultrasonography and angiogenesis. Microbubbles and micelles are also discussed to underline the superior capabilities of NBs for the application. NBs could passively accumulate to tumor tissue by enhanced permeability and retention effect. In addition, it can also achieve the active transportation by surface modification. Active targeting modalities and stimuli-responsive drug delivery modifications generate a therapeutic vehicle. The cytotoxicity of NBs formulations, multimodal imaging capability, active targeting mechanisms, and drug delivery methods are highlighted to confirm the NB as a vehicle for targeted treatment and enhanced ultrasound imaging. ? 2019 IOP Publishing Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061976891&doi=10.1088%2f1361-6528%2faafeb9&partnerID=40&md5=ee6961a185c48c94f84630e7ccbb7809 https://scholars.lib.ntu.edu.tw/handle/123456789/415888 |
DOI: | 10.1088/1361-6528/aafeb9 | SDG/關鍵字: | Biocompatibility; Chemotherapy; Controlled drug delivery; Diagnosis; Drug delivery; Micelles; Tumors; Ultrasonic applications; Ultrasonography; Active targeting; Active transportations; Contrast enhanced ultrasound; Enhanced Permeability and Retention effect; Nanobubbles; Stimuli-responsive drug deliveries; theranostic; Ultrasound contrast agent; Targeted drug delivery; contrast medium; nanoparticle; diagnostic imaging; drug delivery system; drug effect; drug resistance; echography; human; microbubble; neoplasm; procedures; theranostic nanomedicine; Contrast Media; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Microbubbles; Nanoparticles; Neoplasms; Theranostic Nanomedicine; Ultrasonography |
顯示於: | 化學系 |
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