https://scholars.lib.ntu.edu.tw/handle/123456789/416256
標題: | ROG, repressor of GATA, regulates the expression of cytokine genes | 作者: | SHI-CHUEN MIAW Choi, Andrew Yu, Elaine Kishikawa, Hiroko Ho, I. Cheng |
公開日期: | 1-一月-2000 | 卷: | 12 | 期: | 3 | 起(迄)頁: | 323 | 來源出版物: | Immunity | 摘要: | GATA-3 is a T cell-specific transcription factor and is essential for the development of the T cell lineage. Recently, it was shown that the expression of GATA-3 is further induced in CD4+ helper T cells upon differentiation into type 2 but not type 1 effector cells. Here, we report the molecular cloning of a GATA-3 interacting protein, repressor of GATA (ROG). ROG is a lymphoid-specific gene and is rapidly induced in Th cells upon stimulation with anti-CD3. In in vitro assays, ROG represses the GATA-3-induced transactivation. Furthermore, overexpression of ROG in Th clones inhibits the production of Th cytokines. Taken together, our results suggest that ROG might play a critical role in regulating the differentiation and activation of Th cells. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033696204&doi=10.1016%2fS1074-7613%2800%2980185-5&partnerID=40&md5=d1eca14e1abde9ead8ea28d2972b243e https://scholars.lib.ntu.edu.tw/handle/123456789/416256 |
ISSN: | 10747613 | DOI: | 10.1016/S1074-7613(00)80185-5 |
顯示於: | 免疫學研究所 |
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