https://scholars.lib.ntu.edu.tw/handle/123456789/416259
標題: | ROG negatively regulates T-cell activation but is dispensable for Th-cell differentiation | 作者: | Kang, Bok Yun SHI-CHUEN MIAW Ho, I-Cheng |
公開日期: | 一月-2005 | 出版社: | AMER SOC MICROBIOLOGY | 卷: | 25 | 期: | 2 | 起(迄)頁: | 554 | 來源出版物: | Molecular and cellular biology | 摘要: | ROG, a transcriptional repressor, is a direct target gene of NF-AT and a putative negative regulator of T-cell activation. In addition, overexpression of ROG suppresses the activity of GATA-3, implying a role of ROG in the differentiation and function of Th cells. Despite these observations, the function of ROG has yet to be confirmed by loss-of-function approaches. Here we report that ROG-deficient T cells are hypersensitive to anti-CD3 stimulation and produce more interleukin-2 (IL-2) due to enhanced NF-kappaB activity. ROG-deficient dendritic cells also produce more IL-12p40, another NF-kappaB target gene. However, ROG-deficient Th cells are capable of differentiating into Th1 and Th2 cells, and ROG-deficient mice have no defect in mounting appropriate Th immune responses in vivo. Thus, ROG is dispensable for the differentiation and function of Th cells but serves as a mediator of NF-AT-initiated suppression of NF-kappaB. Its mechanism of action and its expression pattern are distinct from those of other transcription factors negatively regulating the activation of T cells. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-11844291981&doi=10.1128%2fMCB.25.2.554-562.2005&partnerID=40&md5=a1b532c394c34970296110fba4232f08 https://scholars.lib.ntu.edu.tw/handle/123456789/416259 |
ISSN: | 0270-7306 | DOI: | 10.1128/MCB.25.2.554-562.2005 |
顯示於: | 免疫學研究所 |
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