https://scholars.lib.ntu.edu.tw/handle/123456789/416281
標題: | Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22 | 作者: | Liu, Chih-Chun Lai, Chen-Yen Yen, Wei-Feng Lin, Yu-Hsien Chang, Hui-Hsin Tai, Tzong-Shyuan Lu, Yu-Jung Tsao, Hsiao-Wei Ho, I-Cheng SHI-CHUEN MIAW |
公開日期: | 2015 | 出版社: | PUBLIC LIBRARY SCIENCE | 卷: | 10 | 期: | 5 | 來源出版物: | PloS one | 摘要: | C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine phosphorylation remains unknown. In this study, we demonstrate that Tec kinase family member Tec, but not Rlk or Itk, is a tyrosine kinase of c-Maf and that Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity. We further show that phosphorylation of Tyr21/92/131 of c-Maf is also critical for its recruitment to the IL-21 promoter and optimal production of this cytokine by TH17 cells. Thus, manipulating tyrosine phosphorylation of c-Maf through its kinases and phosphatases can have significant impact on TH cell-mediated immune responses. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930642701&doi=10.1371%2fjournal.pone.0127617&partnerID=40&md5=a0e4fe5c9d8d85c8921d02b490320d73 https://scholars.lib.ntu.edu.tw/handle/123456789/416281 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0127617 |
顯示於: | 免疫學研究所 |
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