|Title:||HAHap: a read-based haplotyping method using hierarchical assembly||Authors:||Lin, Yu-Yu
Wu, Ping Chun
|Keywords:||Haplotype; Hierarchical assembly; Probability score; Read-based phasing||Issue Date:||2018||Publisher:||PEERJ INC||Journal Volume:||6||Source:||PeerJ||Abstract:||
The need for read-based phasing arises with advances in sequencing technologies. The minimum error correction (MEC) approach is the primary trend to resolve haplotypes by reducing conflicts in a single nucleotide polymorphism-fragment matrix. However, it is frequently observed that the solution with the optimal MEC might not be the real haplotypes, due to the fact that MEC methods consider all positions together and sometimes the conflicts in noisy regions might mislead the selection of corrections. To tackle this problem, we present a hierarchical assembly-based method designed to progressively resolve local conflicts.
|Appears in Collections:||基因體暨蛋白體醫學研究所|
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