https://scholars.lib.ntu.edu.tw/handle/123456789/416730
標題: | Multiple activities of Arl1 GTPase in the trans-Golgi network | 作者: | Yu, Chia-Jung Fang-Jen Scott Lee |
關鍵字: | Arf; Endosome; GAP; GEF; GTPase; Golgi complex; Golgin; Membrane trafficking | 公開日期: | 2017 | 出版社: | COMPANY BIOLOGISTS LTD | 卷: | 130 | 期: | 10 | 起(迄)頁: | 1691 | 來源出版物: | Journal of cell science | 摘要: | ADP-ribosylation factors (Arfs) and ADP-ribosylation factor-like proteins (Arls) are highly conserved small GTPases that function as main regulators of vesicular trafficking and cytoskeletal reorganization. Arl1, the first identified member of the large Arl family, is an important regulator of Golgi complex structure and function in organisms ranging from yeast to mammals. Together with its effectors, Arl1 has been shown to be involved in several cellular processes, including endosomal trans-Golgi network and secretory trafficking, lipid droplet and salivary granule formation, innate immunity and neuronal development, stress tolerance, as well as the response of the unfolded protein. In this Commentary, we provide a comprehensive summary of the Arl1-dependent cellular functions and a detailed characterization of several Arl1 effectors. We propose that involvement of Arl1 in these diverse cellular functions reflects the fact that Arl1 is activated at several late-Golgi sites, corresponding to specific molecular complexes that respond to and integrate multiple signals. We also provide insight into how the GTP-GDP cycle of Arl1 is regulated, and highlight a newly discovered mechanism that controls the sophisticated regulation of Arl1 activity at the Golgi complex. |
URI: | https://api.elsevier.com/content/abstract/scopus_id/85019197486 https://scholars.lib.ntu.edu.tw/handle/123456789/416730 |
ISSN: | 0021-9533 | DOI: | 10.1242/jcs.201319 |
顯示於: | 分子醫學研究所 |
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