https://scholars.lib.ntu.edu.tw/handle/123456789/416732
標題: | ADP-ribosylation factor-like 4C binding to filamin-A modulates filopodium formation and cell migration | 作者: | Chiang, Tsai-Shin Wu, Hsu-Feng Fang-Jen Scott Lee |
公開日期: | 1-十一月-2017 | 出版社: | AMER SOC CELL BIOLOGY | 卷: | 28 | 期: | 22 | 起(迄)頁: | 3013 | 來源出版物: | Molecular biology of the cell | 摘要: | Changes in cell morphology and the physical forces that occur during migration are generated by a dynamic filamentous actin cytoskeleton. The ADP-ribosylation factor-like 4C (Arl4C) small GTPase acts as a molecular switch to regulate morphological changes and cell migration, although the mechanism by which this occurs remains unclear. Here we report that Arl4C functions with the actin regulator filamin-A (FLNa) to modulate filopodium formation and cell migration. We found that Arl4C interacted with FLNa in a GTP-dependent manner and that FLNa IgG repeat 22 is both required and sufficient for this interaction. We also show that interaction between FLNa and Arl4C is essential for Arl4C-induced filopodium formation and increases the association of FLNa with Cdc42-GEF FGD6, promoting cell division cycle 42 (Cdc42) GTPase activation. Thus our study revealed a novel mechanism, whereby filopodium formation and cell migration are regulated through the Arl4C-FLNa-mediated activation of Cdc42. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032626453&doi=10.1091%2fmbc.E17-01-0059&partnerID=40&md5=85181c9740c8462aadb73b259ebc99e4 https://scholars.lib.ntu.edu.tw/handle/123456789/416732 |
ISSN: | 1059-1524 | DOI: | 10.1091/mbc.E17-01-0059 |
顯示於: | 分子醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。