https://scholars.lib.ntu.edu.tw/handle/123456789/417194
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chou H.-C. | en_US |
dc.contributor.author | Lee, Cha-Ze | en_US |
dc.contributor.author | Ma L.-C. | en_US |
dc.contributor.author | CHI-TAI FANG | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.contributor.author | JIN-TOWN WANG | en_US |
dc.creator | Chou H.-C.;Lee C.-Z.;Ma L.-C.;Fang C.-T.;Chang S.-C.;Wang, Jin-Town | - |
dc.date.accessioned | 2019-09-02T08:58:31Z | - |
dc.date.available | 2019-09-02T08:58:31Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-3042692195&doi=10.1128%2fIAI.72.7.3783-3792.2004&partnerID=40&md5=d6b8c929633b24160c5b4de040d2df3d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/417194 | - |
dc.description.abstract | Klebsiella pneumoniae liver abscess with metastatic complications is an emerging infectious disease in Taiwan. To identify genes associated with liver infection, we used a DNA microarray to compare the transcriptional profiles of three strains causing liver abscess and three strains not associated with liver infection. There were 13 clones that showed higher RNA expression levels in the three liver infection strains, and 3 of these 13 clones contained a region that was absent in MGH 78578. Sequencing of the clones revealed the replacement of 149 bp of MGH 78578 with a 21,745-bp fragment in a liver infection strain, NTUH-K2044. This 21,745-bp fragment contained 19 open reading frames, 14 of which were proven to be associated with allantoin metabolism. The K2044)(ΔallS) mutant showed a significant decrease of virulence in intragastric inoculation of BALB/c mice, and the prevalence of this chromosomal region was significantly higher in strains associated with liver abscess than in those that were not (19 or 32 versus 2 of 94; P = 0.0001 [χ2 test]). Therefore, the 22-kb region may play a role in K. pneumoniae liver infection and serve as a marker for rapid identification. | en_US |
dc.language.iso | en_US | en_US |
dc.relation.ispartof | Infection and Immunity | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | allantoin; animal experiment; animal model; article; bacterial strain; bacterial virulence; bacterium isolation; chromosome isolation; controlled study; DNA microarray; female; gene expression; genetic association; hepatitis; human; inoculation; Klebsiella pneumoniae; liver abscess; metabolism; mouse; nonhuman; nucleotide sequence; priority journal; sequence analysis; Allantoin; Amino Acid Sequence; Animals; Base Sequence; Female; Infection; Klebsiella pneumoniae; Liver; Liver Abscess; Mice; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; RNA, Messenger | - |
dc.title | Isolation of a chromosomal region of Klebsiella pneumoniae associated with allantoin metabolism and liver infection | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1128/IAI.72.7.3783-3792.2004 | - |
dc.identifier.pmid | 15213119 | - |
dc.identifier.scopus | 2-s2.0-3042692195 | - |
dc.relation.pages | 3783-3792 | en_US |
dc.relation.journalvolume | 72 | en_US |
dc.relation.journalissue | 7 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-0974-3527 | - |
crisitem.author.orcid | 0000-0002-7380-1699 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.orcid | 0000-0002-1595-6801 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 微生物學科所 |
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