https://scholars.lib.ntu.edu.tw/handle/123456789/417361
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHUN-YU WU | en_US |
dc.contributor.author | LU, YI-FAN | en_US |
dc.contributor.author | MAN-LING WANG | en_US |
dc.contributor.author | JIN-SHING CHEN | en_US |
dc.contributor.author | YEN-CHUN HSU | en_US |
dc.contributor.author | Yang, Fu-Sui | en_US |
dc.contributor.author | YA-JUNG CHENG | en_US |
dc.creator | Chun-Yu Wu;Lu, Yi-Fan;Man-Ling Wang;Jin-Shing Chen;Yen-Chun Hsu;Yang, Fu-Sui;Ya-Jung Cheng | - |
dc.date.accessioned | 2019-09-04T07:34:11Z | - |
dc.date.available | 2019-09-04T07:34:11Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0962-9351 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054097781&doi=10.1155%2f2018%2f2575910&partnerID=40&md5=bcc6e49397348a363aae896c28fd49ca | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/417361 | - |
dc.description.abstract | One-lung ventilation in thoracic surgery provokes profound systemic inflammatory responses and injury related to lung tidal volume changes. We hypothesized that the highly selective a2-adrenergic agonist dexmedetomidine attenuates these injurious responses. Sixty patients were randomly assigned to receive dexmedetomidine or saline during thoracoscopic surgery. There is a trend of less postoperative medical complication including that no patients in the dexmedetomidine group developed postoperative medical complications, whereas four patients in the saline group did (0% versus 13.3%, p = 0.1124). Plasma inflammatory and injurious biomarkers between the baseline and after resumption of two-lung ventilation were particularly notable. The plasma high-mobility group box 1 level decreased significantly from 51.7 (58.1) to 33.9 (45.0) ng.ml-1 (p < 0.05) in the dexmedetomidine group, which was not observed in the saline group. Plasma monocyte chemoattractant protein 1 [151.8 (115.1) to 235.2 (186.9) pg.ml-1, p < 0.05] and neutrophil elastase [350.8 (154.5) to 421.9 (106.1) ng.ml-1, p < 0.05] increased significantly only in the saline group. In addition, plasma interleukin-6 was higher in the saline group than in the dexmedetomidine group at postoperative day 1 [118.8 (68.8) versus 78.5 (58.8) pg.ml-1, p = 0.0271]. We conclude that dexmedetomidine attenuates one-lung ventilation-associated inflammatory and injurious responses by inhibiting alveolar neutrophil recruitment in thoracoscopic surgery. | en_US |
dc.language.iso | en | en_US |
dc.publisher | HINDAWI LTD | en_US |
dc.relation.ispartof | Mediators of inflammation | en_US |
dc.title | Effects of Dexmedetomidine Infusion on Inflammatory Responses and Injury of Lung Tidal Volume Changes during One-Lung Ventilation in Thoracoscopic Surgery: A Randomized Controlled Trial | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1155/2018/2575910 | - |
dc.identifier.pmid | 29853785 | - |
dc.identifier.scopus | 2-s2.0-85054097781 | - |
dc.identifier.isi | WOS:000433332200001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85054097781 | - |
dc.relation.journalvolume | 2018 | en_US |
dc.relation.pageend | 8 | en_US |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology-NTUCC | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Anesthesiology-NTUCC | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.orcid | 0000-0002-9544-8654 | - |
crisitem.author.orcid | 0000-0002-7097-7189 | - |
crisitem.author.orcid | 0000-0001-5077-4483 | - |
crisitem.author.orcid | 0000-0002-6333-6463 | - |
crisitem.author.orcid | 0000-0001-9150-4690 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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