標題: | Ameliorative effects of D-glucuronolactone on oxidative stress and inflammatory/fibrogenic responses in livers of thioacetamide-treated rats |
作者: | Chen, PJ Chiu, CH Tseng, JK Yang, KT YI-CHEN CHEN CHIH-HSIEN CHIU |
關鍵字: | Anti-inflammation; Antioxidant; D-glucuronolactone; Liver fibrosis; Thioacetamide |
公開日期: | 2015 |
出版社: | ELSEVIER SCIENCE BV |
卷: | 14 |
起(迄)頁: | 154 |
來源出版物: | JOURNAL OF FUNCTIONAL FOODS |
摘要: | © 2015 Elsevier Ltd. D-Glucuronolactone (C6H8O6, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75mgkg-1 bw glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100mgkg-1 bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p<0.05). Down-regulated (p<0.05) expression of inflammation including interleukin-6 (IL-6), nuclear factor-kappa B (NF-κB), activator protein 1 (AP-1), krüppel-like factor 6 (KLF-6), and fibrosis related fibrotic factors, i.e., alpha smooth muscle actin (α-SMA), and collagen alpha1 (I) (COLα1) through lactone supplementation underlay the lower collagen contents and less severe liver damage on histopathology observations. Therefore, hepatoprotection of lactone against TAA-induced liver fibrosis can be attributed to the amelioration of oxidative stress and inflammation. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/425194 |
ISSN: | 1756-4646 |
DOI: | 10.1016/j.jff.2015.01.026 |
顯示於: | 動物科學技術學系
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