https://scholars.lib.ntu.edu.tw/handle/123456789/425194
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen, PJ | en_US |
dc.contributor.author | Chiu, CH | en_US |
dc.contributor.author | Tseng, JK | en_US |
dc.contributor.author | Yang, KT | en_US |
dc.contributor.author | YI-CHEN CHEN | en_US |
dc.contributor.author | CHIH-HSIEN CHIU | en_US |
dc.creator | Chen, YC;Yang, KT;Tseng, JK;Chiu, CH;Chen, PJ | - |
dc.date.accessioned | 2019-09-26T06:30:43Z | - |
dc.date.available | 2019-09-26T06:30:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/425194 | - |
dc.description.abstract | © 2015 Elsevier Ltd. D-Glucuronolactone (C<inf>6</inf>H<inf>8</inf>O<inf>6</inf>, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75mgkg<sup>-1</sup> bw glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100mgkg<sup>-1</sup> bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p<0.05). Down-regulated (p<0.05) expression of inflammation including interleukin-6 (IL-6), nuclear factor-kappa B (NF-κB), activator protein 1 (AP-1), krüppel-like factor 6 (KLF-6), and fibrosis related fibrotic factors, i.e., alpha smooth muscle actin (α-SMA), and collagen alpha1 (I) (COLα1) through lactone supplementation underlay the lower collagen contents and less severe liver damage on histopathology observations. Therefore, hepatoprotection of lactone against TAA-induced liver fibrosis can be attributed to the amelioration of oxidative stress and inflammation. | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.relation.ispartof | JOURNAL OF FUNCTIONAL FOODS | en_US |
dc.subject | Anti-inflammation; Antioxidant; D-glucuronolactone; Liver fibrosis; Thioacetamide | en_US |
dc.title | Ameliorative effects of D-glucuronolactone on oxidative stress and inflammatory/fibrogenic responses in livers of thioacetamide-treated rats | en_US |
dc.identifier.doi | 10.1016/j.jff.2015.01.026 | - |
dc.identifier.scopus | 2-s2.0-84926393740 | - |
dc.identifier.isi | WOS:000364500000016 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84926393740 | - |
dc.relation.pages | 154 | en_US |
dc.relation.journalvolume | 14 | en_US |
dc.relation.pageend | 162 | en_US |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Master Program in Global Agriculture Technology and Genomic Science (Global ATGS) | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.orcid | 0000-0002-4616-2115 | - |
crisitem.author.orcid | 0000-0002-1209-3852 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 動物科學技術學系 |
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