https://scholars.lib.ntu.edu.tw/handle/123456789/425204
標題: | Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis | 作者: | Chen, I-Shu YI-CHEN CHEN CHUNG-HSI CHOU Chuang, Ruei-Feng LEE-YAN SHEEN CHIH-HSIEN CHIU |
關鍵字: | thioacetami de; chronic liverfibrosis; silymarin; MMP; TIMP families; hepatic stellate cell activation | 公開日期: | 五月-2012 | 出版社: | WILEY-BLACKWELL | 卷: | 92 | 期: | 7 | 起(迄)頁: | 1441 | 來源出版物: | Journal of the science of food and agriculture | 摘要: | Liver fibrosis is chronic liver damage usually caused by alcohol, viruses or other toxins and is characterised by an excessive accumulation of extracellular matrix proteins such as collagen. The aim of this study was to establish an animal model of chronic liver damage and investigate molecular mechanisms of silymarin hepatoprotective effects. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/425204 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859429176&doi=10.1002%2fjsfa.4723&partnerID=40&md5=88d5a5d70f32918285e50339b5b5c20c |
ISSN: | 00225142 | DOI: | 10.1002/jsfa.4723 | SDG/關鍵字: | cholesterol; matrix metalloproteinase; plant extract; silymarin; thioacetamide; tissue inhibitor of metalloproteinase; transcription factor AP 1; transforming growth factor beta1; triacylglycerol; animal; article; blood; body weight; chemistry; chronic disease; disease model; down regulation; drug effect; experimental liver cirrhosis; Institute for Cancer Research mouse; liver; male; metabolism; mouse; organ size; pathology; phytotherapy; randomization; Silybum marianum; toxic hepatitis; Animals; Body Weight; Cholesterol; Chronic Disease; Disease Models, Animal; Down-Regulation; Drug-Induced Liver Injury; Liver; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinases; Mice; Mice, Inbred ICR; Milk Thistle; Organ Size; Phytotherapy; Plant Extracts; Random Allocation; Silymarin; Thioacetamide; Tissue Inhibitor of Metalloproteinases; Transcription Factor AP-1; Transforming Growth Factor beta1; Triglycerides; Animalia; Mus |
顯示於: | 動物科學技術學系 |
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