https://scholars.lib.ntu.edu.tw/handle/123456789/425361
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang L.L. | en_US |
dc.contributor.author | Highley C.B. | en_US |
dc.contributor.author | Yeh Y.-C. | en_US |
dc.contributor.author | Galarraga J.H. | en_US |
dc.contributor.author | Uman S. | en_US |
dc.contributor.author | Burdick J.A. | en_US |
dc.contributor.author | YI-CHEUN YEH | en_US |
dc.creator | Burdick J.A.;Uman S.;Galarraga J.H.;Yeh Y.-C.;Highley C.B.;Wang L.L.;YI-CHEUN YEH | - |
dc.date.accessioned | 2019-09-26T08:31:10Z | - |
dc.date.available | 2019-09-26T08:31:10Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 15493296 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/425361 | - |
dc.description.abstract | The fabrication of three-dimensional (3D) scaffolds is indispensable to tissue engineering and 3D printing is emerging as an important approach towards this. Hydrogels are often used as inks in extrusion-based 3D printing, including with encapsulated cells; however, numerous challenging requirements exist, including appropriate viscosity, the ability to stabilize after extrusion, and cytocompatibility. Here, we present a shear-thinning and self-healing hydrogel crosslinked through dynamic covalent chemistry for 3D bioprinting. Specifically, hyaluronic acid was modified with either hydrazide or aldehyde groups and mixed to form hydrogels containing a dynamic hydrazone bond. Due to their shear-thinning and self-healing properties, the hydrogels could be extruded for 3D printing of structures with high shape fidelity, stability to relaxation, and cytocompatibility with encapsulated fibroblasts (>80% viability). Forces for extrusion and filament sizes were dependent on parameters such as material concentration and needle gauge. To increase scaffold functionality, a second photocrosslinkable interpenetrating network was included that was used for orthogonal photostiffening and photopatterning through a thiol-ene reaction. Photostiffening increased the scaffold's modulus (?300%) while significantly decreasing erosion (?70%), whereas photopatterning allowed for spatial modification of scaffolds with dyes. Overall, this work introduces a simple approach to both fabricate and modify 3D printed scaffolds. ? 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 865¡V875, 2018. ? 2018 Wiley Periodicals, Inc. | - |
dc.language | English | - |
dc.relation.ispartof | Journal of Biomedical Materials Research - Part A | - |
dc.subject | 3D printing | - |
dc.subject | dynamic covalent chemistry | - |
dc.subject | hydrazone | - |
dc.subject | hydrogel | - |
dc.subject | injectable | - |
dc.title | Three-dimensional extrusion bioprinting of single- and double-network hydrogels containing dynamic covalent crosslinks | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/jbm.a.36323 | - |
dc.identifier.scopus | 2-s2.0-85040784349 | - |
dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85040784349&doi=10.1002%2fjbm.a.36323&partnerID=40&md5=87ff8de7d2089a040b16694bdf230205 | - |
dc.relation.pages | 865-875 | - |
dc.relation.journalvolume | 106 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Polymer Science and Engineering | - |
crisitem.author.parentorg | College of Engineering | - |
顯示於: | 高分子科學與工程學研究所 |
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