|Title:||Mass spectrometric detection of nanoparticle host-guest interactions in cells||Authors:||Yan B.
Yesilbag Tonga G.
|Issue Date:||2014||Journal Volume:||86||Journal Issue:||13||Start page/Pages:||6710-6714||Source:||Analytical Chemistry||Abstract:||
Synthetic host-guest chemistry is a versatile tool for biomedical applications. Characterization and detection of host-guest complexes in biological systems, however, is challenging due to the complexity of the biological milieu. Here, we describe and apply a mass spectrometric method to monitor the association and dissociation of nanoparticle (NP)-based host-guest interactions that integrates NP-assisted laser desorption/ionization (LDI) and matrix assisted laser desoption/ionization (MALDI) mass spectrometry. This LDI/MALDI approach reveals how NP surface functionality affects host-guest interactions in cells, information difficult to achieve using other techniques. ? 2014 American Chemical Society.
|Appears in Collections:||高分子科學與工程學研究所|
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