https://scholars.lib.ntu.edu.tw/handle/123456789/425372
Title: | Mass spectrometric detection of nanoparticle host-guest interactions in cells | Authors: | Yan B. Yesilbag Tonga G. Hou S. Fedick P.W. Yeh Y.-C. Alfonso F.S. Mizuhara T. Vachet R.W. Rotello V.M. YI-CHEUN YEH |
Issue Date: | 2014 | Journal Volume: | 86 | Journal Issue: | 13 | Start page/Pages: | 6710-6714 | Source: | Analytical Chemistry | Abstract: | Synthetic host-guest chemistry is a versatile tool for biomedical applications. Characterization and detection of host-guest complexes in biological systems, however, is challenging due to the complexity of the biological milieu. Here, we describe and apply a mass spectrometric method to monitor the association and dissociation of nanoparticle (NP)-based host-guest interactions that integrates NP-assisted laser desorption/ionization (LDI) and matrix assisted laser desoption/ionization (MALDI) mass spectrometry. This LDI/MALDI approach reveals how NP surface functionality affects host-guest interactions in cells, information difficult to achieve using other techniques. ? 2014 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/425372 | ISSN: | 00032700 | DOI: | 10.1021/ac501682y https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84903738982&doi=10.1021%2fac501682y&partnerID=40&md5=5584117bb4777dc555e994dcac302672 |
Appears in Collections: | 高分子科學與工程學研究所 |
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ac501682y.pdf | 1.53 MB | Adobe PDF | View/Open |
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