|Title:||Fabrication of multiresponsive bioactive nanocapsules through orthogonal self-assembly||Authors:||Yeh Y.-C.
|Keywords:||nanocapsules;nanoparticles;noncovalent interactions;self-assembly;stimuli-responsive release||Issue Date:||2014||Journal Volume:||53||Journal Issue:||20||Start page/Pages:||5137-5141||Source:||Angewandte Chemie - International Edition||Abstract:||
Multifunctional self-assembled systems present platforms for fundamental research and practical applications as they provide tunability of structure, functionality, and stimuli responsiveness. Pragmatic structures for biological applications have multiple design requirements, including control of size, stability, and environmental response. Here we present the fabrication of multifunctional nanoparticle-stabilized capsules (NPSCs) by using a set of orthogonal supramolecular interactions. In these capsules, fluorescent proteins are attached to quantum dots through polyhistidine coordination. These anionic assemblies interact laterally with cationic gold nanoparticles that are anchored to the fatty acid core through guanidinium-carboxylate interactions. The lipophilic core then provides a reservoir for hydrophobic endosome-disrupting agents, thereby generating a system featuring stimuli-responsive release of a payload into the cytosol with fluorescence monitoring. Multifunctional nanocapsules: Multifunctional nanoparticle-stabilized capsules (NPSCs) have been fabricated by using a set of orthogonal supramolecular interactions. The resultant supramolecular nanocapsules feature dual-delivery capability of proteins and hydrophobic endosome-disrupting agents to allow stimuli-responsive protein release into the cytosol with fluorescence monitoring. ? 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
|Appears in Collections:||高分子科學與工程學研究所|
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