https://scholars.lib.ntu.edu.tw/handle/123456789/425377
標題: | Differentiation of cancer cell type and phenotype using quantum dot-gold nanoparticle sensor arrays | 作者: | Liu Q. Yeh Y.-C. Rana S. Jiang Y. Guo L. Rotello V.M. YI-CHEUN YEH |
關鍵字: | Cell surface differentiation;Gold nanoparticles;Quantum dots;Sensor array | 公開日期: | 2013 | 卷: | 334 | 期: | 2 | 起(迄)頁: | 196-201 | 來源出版物: | Cancer Letters | 摘要: | We demonstrate rapid and efficient sensing of mammalian cell types and states using nanoparticle-based sensor arrays. These arrays are comprised of cationic quantum dots (QDs) and gold nanoparticles (AuNPs) that interact with cell surfaces to generate distinguishable fluorescence responses based on cell surface signatures. The use of QDs as the recognition elements as well as the signal transducers presents the potential for direct visualization of selective cell surface interactions. Notably, this sensor is unbiased, precluding the requirement of pre-knowledge of cell state biomarkers and thus providing a general approach for phenotypic profiling of cell states, with additional potential for imaging applications. ? 2012 Elsevier Ireland Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/425377 | ISSN: | 03043835 | DOI: | 10.1016/j.canlet.2012.09.013 |
顯示於: | 高分子科學與工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。