https://scholars.lib.ntu.edu.tw/handle/123456789/425870
Title: | Neural correlates of impaired self-regulation in male youths with autism spectrum disorder: A voxel-based morphometry study | Authors: | Ni, Hsing Chang HSIANG-YUAN LIN WEN-YIH TSENG YEN-NAN CHIU Wu, Yu Yu WEN-CHE TSAI SUSAN SHUR-FEN GAU |
Keywords: | Autism spectrum disorder | Child behavior checklist | Dysregulation | Structural MRI | Voxel-based morphometry;Autism spectrum disorder; Child behavior checklist; Dysregulation; Structural MRI; Voxel-based morphometry | Issue Date: | 2-Mar-2018 | Journal Volume: | 82 | Source: | Progress in Neuro-Psychopharmacology and Biological Psychiatry | Abstract: | © 2017 The Authors Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7–17 years. Dysregulation was defined by the sum of T-scores of Attention, Aggression, and Anxiety/Depression subscales in the Child Behavior Checklist > 180. There were 53 and 28 boys in the ASD + Dysregulation and ASD-Dysregulation groups, respectively. First, we compared regional gray matter (GM) volume for ASD and TD. Second, we investigated regional GM volumetric differences among the ASD + Dysregulation, ASD-Dysregulation and TD groups. Lastly, shared and distinct neurostructural correlates of dysregulation were investigated in the ASD and TD groups. The ASD-TD difference on neuroanatomy no longer existed after controlling the dysregulation severity. ASD + Dysregulation had larger regional GM volumes in the right fusiform gyrus, and smaller GM volumes in the anterior prefrontal cortex than ASD-Dysregulation and TD, respectively. ASD + Dysregulation had smaller GM volumes in the left lateral occipital/superior parietal cortex than TD boys. No GM difference was identified between ASD-Dysregulation and TD. ASD and TD had a shared association between GM volumes in the orbitofrontal cortex and dysregulation levels. Our findings suggest that atypical neuroanatomy associated with ASD might partially reflect a disproportionate level of impaired self-regulation. Categorical and dimensional considerations of dysregulation should be implemented in future ASD studies. |
URI: | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85034735489&doi=10.1016%2fj.pnpbp.2017.11.008&partnerID=40&md5=4a7f520a3aae3a7b42eea9f42fa86c59 https://scholars.lib.ntu.edu.tw/handle/123456789/425870 |
ISSN: | 02785846 | DOI: | https://api.elsevier.com/content/abstract/scopus_id/85034735489 10.1016/j.pnpbp.2017.11.008 |
SDG/Keyword: | adolescent; aggression; anxiety; Article; attention; autism; autoregulation; brain region; brain size; child; Child Behavior Checklist; clinical feature; controlled study; disease severity; fusiform gyrus; gray matter; human; intelligence quotient; juvenile; major clinical study; male; neuroanatomy; nuclear magnetic resonance imaging; orbital cortex; parietal cortex; prefrontal cortex; scoring system; volumetry; voxel based morphometry; autism; brain; diagnostic imaging; organ size; pathology; psychology; self control; Adolescent; Autism Spectrum Disorder; Brain; Child; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Organ Size; Self-Control |
Appears in Collections: | 醫療器材與醫學影像研究所 |
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