https://scholars.lib.ntu.edu.tw/handle/123456789/425887
Title: | Disorder-Specific Alteration in White Matter Structural Property in Adults With Autism Spectrum Disorder Relative to Adults With ADHD and Adult Controls | Authors: | HUEY-LING CHIANG YU-JEN CHEN HSIANG-YUAN LIN WEN-YIH TSENG SUSAN SHUR-FEN GAU |
Keywords: | attention deficit/hyperactivity disorder | autism spectrum disorder | diffusion spectrum imaging | tractography | white matter;attention deficit/hyperactivity disorder; autism spectrum disorder; diffusion spectrum imaging; tractography; white matter | Issue Date: | 1-Jan-2017 | Journal Volume: | 38 | Journal Issue: | 1 | Start page/Pages: | 384 | Source: | Human Brain Mapping | Abstract: | © 2016 Wiley Periodicals, Inc. Objective: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are not only often comorbid but also overlapped in behavioral and cognitive abnormalities. Little is known about whether these shared phenotypes are based on common or different underlying neuropathologies. Therefore, this study aims to examine the disorder-specific alterations in white matter (WM) structural property. Method: The three comparison groups included 23 male adults with ASD (21.4 ± 3.1 years), 32 male adults with ADHD (23.4 ± 3.3 years), and 29 age-matched healthy male controls (22.4 ± 3.3 years). After acquisition of the diffusion spectrum imaging (DSI), whole brain tractography was reconstructed by a tract-based automatic analysis. Generalized fractional anisotropy (GFA) values were computed to indicate tract-specific WM property with adjusted P value < 0.05 for false discovery rate correction. Results: Post hoc analyses revealed that men with ASD exhibited significant lower GFA values than men with ADHD and male controls in six identified fiber tracts: the right arcuate fasciculus, right cingulum (hippocampal part), anterior commissure, and three callosal fibers (ventrolateral prefrontal cortex part, precentral part, superior temporal part). There was no significant difference in the GFA values of any of the fiber tracts between men with ADHD and controls. In men with ASD, the GFA values of the right arcuate fasciculus and right cingulum (hippocampal part) were negatively associated with autistic social-deficit symptoms, and the anterior commissure GFA value was positively correlated with intelligence. Conclusions: This study highlights the disorder-specific alteration of the microstructural property of WM tracts in male adults with ASD. Hum Brain Mapp 38:384–395, 2017. © 2016 Wiley Periodicals, Inc. |
URI: | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84993949792&doi=10.1002%2fhbm.23367&partnerID=40&md5=4badffb61ce92440bbd3e2590cc776e6 https://scholars.lib.ntu.edu.tw/handle/123456789/425887 |
ISSN: | 10659471 | DOI: | 10.1002/hbm.23367 | SDG/Keyword: | adolescent; adult; anterior commissure; arcuate fasciculus; Article; attention deficit disorder; autism; autoanalysis; cingulum (brain); comparative study; controlled study; diffusion tensor imaging; fractional anisotropy; human; image reconstruction; intelligence quotient; major clinical study; male; nerve fiber; neuroanatomy; neuroimaging; nuclear magnetic resonance scanner; primary motor cortex; priority journal; psychosocial disorder; superior temporal gyrus; ventrolateral prefrontal cortex; white matter; white matter lesion; anisotropy; attention deficit disorder; autism; case control study; diagnostic imaging; female; image processing; myelinated nerve; nuclear magnetic resonance imaging; pathology; severity of illness index; statistics; translating (language); white matter; young adult; Adolescent; Adult; Anisotropy; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Case-Control Studies; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated; Severity of Illness Index; Statistics as Topic; Translating; White Matter; Young Adult |
Appears in Collections: | 醫療器材與醫學影像研究所 |
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