https://scholars.lib.ntu.edu.tw/handle/123456789/425914
標題: | Brain connectomics imaging in schizophrenia study | 作者: | WEN-YIH TSENG YU-JEN CHEN Hsu, Yung Chin |
關鍵字: | Diffusion Spectrum Imaging | Magnetic Resonance Imaging | Schizophrenia | Tract-based automatic analysis | White Matter;Diffusion Spectrum Imaging; Magnetic Resonance Imaging; Schizophrenia; Tract-based automatic analysis; White Matter | 公開日期: | 1-一月-2017 | 出版社: | SPIE | 卷: | 10251 | 來源出版物: | Proceedings of SPIE - The International Society for Optical Engineering | 摘要: | © 2017 SPIE. Schizophrenia is a debilitating mental disorder of which the biological underpinning is still unclear. Increasing evidence in neuroscience has indicated that schizophrenia arises from abnormal connections within or between networks, hence called dysconnectvity syndrome. Recently, we established an automatic method to analyze integrity of the white matter tracts over the whole brain based on diffusion MRI data, named tract-based automatic analysis (TBAA), and used this method to study white matter connection in patients with schizophrenia. We found that alteration of tract integrity is hereditary and inherent; it is found in siblings and in patients in the early phase of disease. Moreover, patients with good treatment outcome and those with poor outcome show distinctly different patterns of alterations, suggesting that these two groups of patients might be distinguishable based on the difference in tract alteration. In summary, the altered tracts revealed by TBAA might become potential biomarkers or trait markers for schizophrenia. |
URI: | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85023743558&doi=10.1117%2f12.2270425&partnerID=40&md5=975b1e33b20177aff538213c26cab5e2 https://scholars.lib.ntu.edu.tw/handle/123456789/425914 |
ISBN: | 9781510610033 | ISSN: | 0277-786X | DOI: | 10.1117/12.2270425 | SDG/關鍵字: | Magnetic resonance imaging; Medical imaging; Patient treatment; Automatic analysis; Biological underpinnings; Diffusion spectrum imaging; Mental disorders; Schizophrenia; Treatment outcomes; White matter; White matter tracts; Diseases |
顯示於: | 醫療器材與醫學影像研究所 |
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