https://scholars.lib.ntu.edu.tw/handle/123456789/426015
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yi-Feng Kao | en_US |
dc.contributor.author | Yi-Hsieng Samuel Wu | en_US |
dc.contributor.author | CHUNG-HSI CHOU | en_US |
dc.contributor.author | Shih-Guei Fu | en_US |
dc.contributor.author | Cheng-Wei Liu | en_US |
dc.contributor.author | Huey-Jine Chai | en_US |
dc.contributor.author | YI-CHEN CHEN | en_US |
dc.creator | Yi-Feng Kao;Yi-Hsieng Samuel Wu;Chung-Hsi Chou;Shih-Guei Fu;Cheng-Wei Liu;Huey-Jine Chai;Yi-Chen Chen | - |
dc.date.accessioned | 2019-10-05T07:43:42Z | - |
dc.date.available | 2019-10-05T07:43:42Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/426015 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050554229&doi=10.1039%2fc8fo00767e&partnerID=40&md5=1cd4ce7ff71c8757d9114013796bcb1f | - |
dc.description.abstract | The anti-inflammation properties of marine phospholipids enriched with n-3 fatty acids contribute to anti-inflammatory and inflammation-resolving mediators. Functional squid-skin (SQ) liposomes were manufactured from squid-skin phospholipids, and their anti-inflammatory effects were investigated. SQ liposomes included phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE), phosphatidylcholine (PC), and lysophosphatidylcholine (Lyso-PC), and had an approximate diameter of 100 mm. When RAW264.7 cells were treated with the SQ liposome, no (p > 0.05) cytotoxicity was observed below a concentration of 7.5 mg mL-1. An SQ-liposome pretreatment of lipopolysaccharide (LPS)-induced RAW 264.7 cells showed decreased (p < 0.05) prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α). The engulfment of SQ liposomes by the RAW264.7 cells resulted in lower (p < 0.05) LPS-induced intracellular levels of reactive oxygen species. Furthermore, an SQ-liposome administration ameliorated (p < 0.05) carrageenan-induced paw edema in mice. SQ liposomes may act via apoptotic mimicry to elicit the resolution of inflammation and prevent chronic inflammation-related diseases. ? The Royal Society of Chemistry. | - |
dc.relation.ispartof | Food & Function | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Fatty acids; Molluscs; Nitric oxide; Pathology; Phospholipids; Shellfish; Anti-inflammatory effects; Chronic inflammation; Intracellular levels; Lysophosphatidyl-choline; Phosphatidylethanolamine; Phosphatidylinositol; Reactive oxygen species; Tumor necrosis factor alpha; Liposomes; antiinflammatory agent; immunoglobulin enhancer binding protein; interleukin 1beta; liposome; nitric oxide; phospholipid; prostaglandin E2; tumor necrosis factor; animal; C57BL mouse; chemistry; Decapodiformes; drug effect; edema; genetics; human; immunology; isolation and purification; macrophage; male; mouse; RAW 264.7 cell line; skin; Animals; Anti-Inflammatory Agents; Decapodiformes; Dinoprostone; Edema; Humans; Interleukin-1beta; Liposomes; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide; Phospholipids; RAW 264.7 Cells; Skin; Tumor Necrosis Factor-alpha | - |
dc.title | Manufacture characterization of anti-inflammatory liposomes from jumbo flying squid (Dosidicus gigas) skin phospholipid extraction | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1039/c8fo00767e | - |
dc.identifier.pmid | 29974091 | - |
dc.identifier.scopus | 2-s2.0-85050554229 | - |
dc.relation.pages | 3986-3996 | - |
dc.relation.journalvolume | 9 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.dept | Office of Student Affairs | - |
crisitem.author.dept | Master Program in Global Agriculture Technology and Genomic Science (Global ATGS) | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Master Program in Global Agriculture Technology and Genomic Science (Global ATGS) | - |
crisitem.author.orcid | 0000-0002-4983-2786 | - |
crisitem.author.orcid | 0000-0002-4616-2115 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | International College | - |
顯示於: | 動物科學技術學系 |
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