https://scholars.lib.ntu.edu.tw/handle/123456789/426406
標題: | Faraday waves-based integrated ultrasonic micro-droplet generator and applications | 作者: | Tsai, Chen S. et al. Mao, Rong W. Tsai, Shirley C. Shahverdi, Kaveh Zhu, Yun Lin, Shih K. HSU, YU-HSIANG Boss, Gerry Brenner, Matt Mahon, Sari Smaldone, Gerald C. |
關鍵字: | Clogging free | Faraday instability | Faraday waves | Integrated ultrasonic nebulizer | MFH ultrasonic nozzle | Monodisperse | Multiple Fourier horns (MFH) | Onset threshold for droplet ejection | Polydisperse | Pulmonary (inhalation) drug delivery | Ultrasonic micro droplet generator | Ultrasonic nebulizer | 公開日期: | 1-二月-2017 | 出版社: | MDPI AG | 卷: | 8 | 期: | 2 | 來源出版物: | Micromachines | 摘要: | © 2017 by the authors. An in-depth review on a new ultrasonic micro-droplet generator which utilizes megahertz (MHz) Faraday waves excited by silicon-based multiple Fourier horn ultrasonic nozzles (MFHUNs) and its potential applications is presented. The new droplet generator has demonstrated capability for producing micro droplets of controllable size and size distribution and desirable throughput at very low electrical drive power. For comparison, the serious deficiencies of current commercial droplet generators (nebulizers) and the other ultrasonic droplet generators explored in recent years are first discussed. The architecture, working principle, simulation, and design of the multiple Fourier horns (MFH) in resonance aimed at the amplified longitudinal vibration amplitude on the end face of nozzle tip, and the fabrication and characterization of the nozzles are then described in detail. Subsequently, a linear theory on the temporal instability of Faraday waves on a liquid layer resting on the planar end face of the MFHUN and the detailed experimental verifications are presented. The linear theory serves to elucidate the dynamics of droplet ejection from the free liquid surface and predict the vibration amplitude onset threshold for droplet ejection and the droplet diameters. A battery-run pocket-size clogging-free integrated micro droplet generator realized using the MFHUN is then described. The subsequent report on the successful nebulization of a variety of commercial pulmonary medicines against common diseases and on the experimental antidote solutions to cyanide poisoning using the new droplet generator serves to support its imminent application to inhalation drug delivery. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/426406 | ISSN: | 2072-666X | DOI: | 10.3390/mi8020056 https://api.elsevier.com/content/abstract/scopus_id/85013916896 |
顯示於: | 應用力學研究所 |
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Supplemental Publication No. 5.pdf | 5.98 MB | Adobe PDF | 檢視/開啟 |
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