https://scholars.lib.ntu.edu.tw/handle/123456789/426657
標題: | Radio-guided sentinel lymph node biopsy using periareolar injection technique for patients with early breast cancer | 作者: | RUOH-FANG YEN WEN-HUNG KUO HUANG-CHUN LIEN Chen, Tony Hsiu Hsi I-SHIOW JAN YEN-WEN WU Wang, Ming Yang KING-JEN CHANG CHIUN-SHENG HUANG |
關鍵字: | 99m Tc radiocolloid | Breast cancer | Periareolar injection | Sentinel lymp node biopsy | 公開日期: | 1-一月-2007 | 卷: | 106 | 期: | 1 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Sentinel lymph node (LN) biopsy has been widely adopted in the axillary staging of clinical node-negative breast cancer patients. This study aimed to evaluate the accuracy of radio-guided sentinel LN (SLN) biopsy (SLNB) using the periareolar injection technique for predicting the histopathologic status of axillary LNs in early breast cancer patients. Methods: Between November 2003 and November 2004 in the National Taiwan University Hospital, radio-guided SLNB using the periareolar injection technique was consecutively performed in 213 female patients with early breast cancer (stage T1 and T2) but without clinically palpable axillary LN and previous chemotherapy. Two mCi of filtered (0.22 μm) 99mTc-sulfur colloid were injected in the afternoon 1 day before surgery (2-day protocol) or 1 mCi of the same radiopharmaceutical was injected on the morning of the surgery (1-day protocol). During surgery, a handheld gamma probe was used to identify the LNs with radioactivity in the axilla. A node was deemed a SLN if its radioactivity was > 10% of the hottest node. All the SLNs identified were removed for histology. Results: Radioactive SLN was identified at surgery in 207 patients. The SLN identification rate was 97.2% (207/213). Of these 207 patients, 163 patients had received both SLNB and axillary LN dissection. Among these 163 patients, 77 patients had LN metastases and four had negative SLN but positive non-SLN. The false-negative rate of SLNB for the detection of axillary LN metastases was 5.2% (4/77). There were no statistical differences between false-negative and SLN positive groups for all factors. Conclusion: Our study suggests that SLNB with periareolar injection of radiocolloid provides valuable information on the axillary nodal status in patients with early breast cancer. © 2007 Elsevier & Formosan Medical Association. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/426657 | ISSN: | 09296646 | DOI: | 10.1016/S0929-6646(09)60215-1 | SDG/關鍵字: | cobalt 57; technetium sulfur colloid tc 99m; adult; aged; article; biopsy technique; breast cancer; cancer staging; clinical protocol; clinical trial; controlled clinical trial; controlled study; diagnostic accuracy; diagnostic value; dosage schedule comparison; false negative result; female; histopathology; human; lymph node dissection; lymph node metastasis; lymphoscintigraphy; major clinical study; patient positioning; preoperative evaluation; radioisotope diagnosis; scintillation camera; sentinel lymph node biopsy; surgical technique |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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