https://scholars.lib.ntu.edu.tw/handle/123456789/426865
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YA-FANG CHEN | en_US |
dc.contributor.author | SUNG-CHUN TANG | en_US |
dc.contributor.author | Wu Wen-Chau | en_US |
dc.contributor.author | HSIEN-LI KAO | en_US |
dc.contributor.author | Kuo Y.-S. | en_US |
dc.contributor.author | Yang S.-C. | en_US |
dc.creator | Ya-Fang Chen;Tang S.-C;Wu Wen-Chau;Kao H.-L;Kuo Y.-S;Yang S.-C. | - |
dc.date.accessioned | 2019-10-18T01:19:47Z | - |
dc.date.available | 2019-10-18T01:19:47Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019207941&doi=10.1038%2fs41598-017-02094-4&partnerID=40&md5=f4d56cf29907b809bddc5694436562db | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/426865 | - |
dc.description.abstract | Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-labeling (ASL) magnetic resonance (MR) imaging. Forty-two patients diagnosed with asymptomatic ICA stenosis/occlusion were prospectively included and divided into high-grade (ultrasonographic stenosis ?70%, N = 20) and low-grade groups (N = 22). On a 3-Tesla clinical MR scanner, pseudo-continuous ASL was performed to measure cerebral blood flow CBF, arterial transit time ATT, and flow territory. Fisher's exact test indicates that the high-grade group has higher frequency in asymmetric ATT (p < 10-3) and asymmetric flow territory (p < 10-3) as compared to the low-grade group. The between-group difference in CBF asymmetry is marginal (p = 0.062). Logistic regression further reveals that hemispherical asymmetry in ATT and flow territory is associated with the existence of high-grade ICA stenosis (odds ratio = 12 and 21, respectively), whereas hemispherical asymmetry in CBF is not. Our data suggest that ATT and flow territory may be better predictors of asymptomatic high-grade ICA stenosis diagnosed by carotid ultrasonography than CBF. ? 2017 The Author(s). | - |
dc.language.iso | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aged; asymptomatic disease; brain circulation; brain cortex; carotid artery obstruction; female; human; image processing; internal carotid artery; magnetic resonance angiography; male; middle aged; nuclear magnetic resonance imaging; pathology; pathophysiology; severity of illness index; vascularization; very elderly; Aged; Aged, 80 and over; Asymptomatic Diseases; Carotid Artery, Internal; Carotid Stenosis; Cerebral Cortex; Cerebrovascular Circulation; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Severity of Illness Index | - |
dc.title | Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-017-02094-4 | - |
dc.identifier.pmid | 28500300 | - |
dc.identifier.scopus | 2-s2.0-85019207941 | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 1 | - |
item.languageiso639-1 | English | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Master's Program in Smart Medicine and Health Informatics (SMARTMHI) | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-2995-9189 | - |
crisitem.author.orcid | 0000-0003-3731-5973 | - |
crisitem.author.orcid | 0000-0002-4040-2771 | - |
crisitem.author.orcid | 0000-0002-5278-3540 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫療器材與醫學影像研究所 |
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