https://scholars.lib.ntu.edu.tw/handle/123456789/427339
標題: | Elevated plasma YKL-40 level is found in the dogs with cancer and is related to poor prognosis | 作者: | Cheng, Kai Chung JIH-JONG LEE SHANG-LIN WANG Lin, Chun-Yu Tseng, Ching-Tien CHEN-SI LIN TAI-CHING LIAO |
關鍵字: | Autoantibodies | Autoantigens | Canine cancer | Prognosis | YKL-40;Autoantibodies; Autoantigens; Canine cancer; Prognosis; YKL-40 | 公開日期: | 1-一月-2019 | 卷: | 20 | 期: | 5 | 來源出版物: | Journal of Veterinary Science | 摘要: | © 2019 The Korean Society of Veterinary Science. YKL-40, a secreted glycoprotein, may serve as an autoantigen, which mediates multiple inflammatory diseases and cancers. A high YKL-40 serum level is correlated with metastasis and poor survival in a variety of human cancers. However, the role of YKL-40 in dogs is still under evaluation. Herein, we examined the associations between plasma YKL-40 level and YKL-40 autoantibody (YAA) titers with malignancy and prognosis in canine cancer. Plasma levels of YKL-40 in healthy dogs (n = 20) and in dogs (n = 82) with cancer were evaluated using enzyme-linked immunosorbent assay. Our results indicated that plasma YKL-40 levels were significantly higher (p < 0.01) in dogs with cancer than in healthy dogs. A significant decrease in the YAA titers was detected in the dogs with cancer when compared with those of the healthy dogs (p < 0.05), although the change was not correlated with the YKL-40 levels. Among the dogs with cancer, plasma YKL-40 levels in the dogs that later relapsed or had metastasis were significantly higher than in the dogs with no signs of relapse (p < 0.01) or metastasis (p <0.05). The relapse and metastasis rates were significantly higher in the high YKL-40 group (> 180 pg/mL) than in the low YKL-40 group (< 180 pg/mL). The results imply that plasma YKL-40 levels might have the potential to be developed as a marker of malignancy progression and prognosis in canine cancers. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/427339 | ISSN: | 1229845X | DOI: | 10.4142/jvs.2019.20.e53 | SDG/關鍵字: | chitinase 3 like protein 1; tumor marker; animal; blood; dog; dog disease; metabolism; neoplasm; prognosis; veterinary medicine; Animals; Biomarkers, Tumor; Chitinase-3-Like Protein 1; Dog Diseases; Dogs; Neoplasms; Prognosis |
顯示於: | 獸醫學系 |
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