https://scholars.lib.ntu.edu.tw/handle/123456789/428867
標題: | Assessment of liver cirrhosis for patients with Child's A classification before hepatectomy using dynamic contrast-enhanced MRI | 作者: | YUNN-SHIUAN LIAO Lee, L. W. Yang, P. H. Kuo, L. M. Kuan, L. Y. WEN-YIH TSENG Hwang, D. W. |
公開日期: | 1-五月-2019 | 卷: | 74 | 期: | 5 | 來源出版物: | Clinical Radiology | 摘要: | © 2019 AIM: To determine the feasibility of semi-quantitative haemodynamic parameters derived from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to assess liver fibrosis. MATERIALS AND METHODS: Seventy-five patients with Child's A classification (males/females=24/51; average age, 58 years; range, 30–80 years) received DCE-MRI 3 days prior to hepatectomy. Semi-quantitative haemodynamic parameters, including the wash-in slope, wash-out slope, and time-to-peak, were calculated from DCE-MRI data. Liver fibrosis of the resected non-tumour liver was graded pathologically from F0 (no fibrosis) to F6 (cirrhosis) in the regions corresponding to those assessed by DCE-MRI. RESULTS: The wash-out slope showed higher interobserver and intra-observer reliabilities than the wash-in slope and time-to-peak. There was a significant positive correlation between the wash-out slope and pathological grade of fibrosis (Spearman's correlation coefficient: r=0.5331, p<0.0001). The area under the receiver operating characteristic curve was 0.8066 when using the wash-out slope to differentiate cirrhosis (grade F6) from non-cirrhosis (grades F0–5). Using the cut-off point that maximised specificity, the sensitivity was 62.07%, specificity was 91.30%, positive predictive value was 81.81%, negative predictive value was 79.25%, and accuracy was 80%. CONCLUSIONS: The wash-out slope derived from DCE-MRI might be potentially useful in assessing liver cirrhosis in patients with Child's A classification before hepatectomy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/428867 | ISSN: | 00099260 | DOI: | 10.1016/j.crad.2019.01.017 |
顯示於: | 醫療器材與醫學影像研究所 |
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