https://scholars.lib.ntu.edu.tw/handle/123456789/430910
Title: | Quantification of cardiac pumping mechanics in rats by using the elastance-resistance model based solely on the measured left ventricular pressure and cardiac output | Authors: | CHIH-HSIEN WANG Chang, Ru-Wen EN-TING WU Chang, Chun-Yi HSIEN-LI KAO MING-SHIOU WU YA-JUNG CHENG YIH-SHARNG CHEN KUO-CHU CHANG |
Keywords: | Cardiac performance; Isovolumic contraction; Triangular aortic flow; Ventricular elastance; Ventricular resistance | Issue Date: | Jul-2019 | Publisher: | SPRINGER HEIDELBERG | Journal Volume: | 471 | Journal Issue: | 7 | Start page/Pages: | 935 | Source: | Pflugers Archiv : European journal of physiology | Abstract: | The cardiac pumping mechanics can be characterized by both the maximal systolic elastance (Emax) and theoretical maximum flow (Qmax), which are generated using an elastance-resistance model. The signals required to fit the elastance-resistance model are the simultaneously recorded left ventricular (LV) pressure and aortic flow (Qm), followed by the isovolumic LV pressure. In this study, we evaluated a single-beat estimation technique for determining the Emax and Qmax by using the elastance-resistance model based solely on the measured LV pressure and cardiac output. The isovolumic LV pressure was estimated from the measured LV pressure by using a non-linear least-squares approximation technique. The measured Qm was approximated by an unknown triangular flow (Qtri), which was generated by using a fourth-order derivative of the LV pressure. The Qtri scale was calibrated using the cardiac output. Values of EmaxtriQ and QmaxtriQ obtained using Qtri were compared with those of EmaxmQ and QmaxmQ obtained from the measured Qm. Healthy rats and rats with chronic kidney disease or diabetes mellitus were examined. We found that the LV Emax and Qmax can be approximately calculated using the assumed Qtri, and they strongly correlated with the corresponding values derived from Qm (P < 0.0001; n = 78): EmaxtriQ = 51.9133 + 0.8992 × EmaxmQ (r2 = 0.8257; P < 0.0001); QmaxtriQ = 2.4053 + 0.9767 × QmaxmQ (r2 = 0.7798; P < 0.0001). Our findings suggest that the proposed technique can be a useful tool for determining Emax and Qmax by using a single LV pressure pulse together with cardiac output. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/430910 | ISSN: | 0031-6768 | DOI: | 10.1007/s00424-019-02270-7 | SDG/Keyword: | animal; aorta; heart; heart output; heart rate; heart ventricle function; heart ventricle pressure; male; physiology; rat; systole; Wistar rat; Animals; Aorta; Cardiac Output; Heart; Heart Rate; Male; Rats; Rats, Wistar; Systole; Ventricular Function; Ventricular Pressure |
Appears in Collections: | 醫學系 |
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