https://scholars.lib.ntu.edu.tw/handle/123456789/431109
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yo, Chia Hung | en_US |
dc.contributor.author | Hsein, Yenh Chen | en_US |
dc.contributor.author | Wu, Yi Luen | en_US |
dc.contributor.author | Hsu, Wan Ting | en_US |
dc.contributor.author | MATTHEW HUEI-MING MA | en_US |
dc.contributor.author | Tsai, Cheng Hsien | en_US |
dc.contributor.author | SHYR-CHYR CHEN | en_US |
dc.contributor.author | CHIEN-CHANG LEE | en_US |
dc.creator | CHIEN-CHANG LEE;SHYR-CHYR CHEN;Tsai, Cheng Hsien;MATTHEW HUEI-MING MA;Hsu, Wan Ting;Wu, Yi Luen;Hsein, Yenh Chen;Yo, Chia Hung | - |
dc.date.accessioned | 2019-11-12T04:54:09Z | - |
dc.date.available | 2019-11-12T04:54:09Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.issn | 09248579 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/431109 | - |
dc.description.abstract | © 2019 Elsevier Ltd Objectives: Very few studies have characterised community-onset polymicrobial bloodstream infections (BSIs). This study determined the incidence, risk factors, and outcomes of polymicrobial BSI as compared with monomicrobial BSI in a cohort of patients with community-onset BSIs. Methods: This prospective cohort study enrolled consecutive patients with laboratory confirmed BSIs who were admitted to two tertiary emergency departments in Taiwan between 1 January 2015 and 31 December 2016. It assessed the independent impact of polymicrobial BSIs on survival by a propensity score weighting method. Subsequently, independent clinical predictors were identified with multivariate logistic regression model analysis with internal validation by 10-fold cross validation. Results: Among 1166 patients with community-onset BSI, 133 (10.9%) episodes of polymicrobial BSIs occurred. Anaerobe, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Enterococcus spp., and Candida spp. were the most common isolated microorganisms in polymicrobial BSI. Polymicrobial BSIs were associated with an increased 90-day mortality rate (OR 2.20, 95% CI 1.98–2.60). A prediction model was built to predict polymicrobial BSI with moderate predictability (c statistic = 0.78). Significant predictors included biliary tract infection, nosocomial infection, nursing home residence, stroke, and afebrile presentation. Conclusions: Polymicrobial BSI occurred in approximately 1 in 10 episodes of community-onset BSI and was independently associated with excess mortality. Clinical predictors identified in this study may help guide the prescription of empiric broad-spectrum antibiotics. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | International Journal of Antimicrobial Agents | en_US |
dc.subject | Bacteraemia | Emergency department | Epidemiology | Polymicrobial bloodstream infection | Risk factors | Sepsis | en_US |
dc.subject | Bacteraemia; Emergency department; Epidemiology; Polymicrobial bloodstream infection; Risk factors; Sepsis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antibiotic agent; antiinfective agent; Acinetobacter baumannii; adult; aged; anaerobe; Article; bacterium isolation; biliary tract infection; bloodstream infection; Candida; cerebrovascular accident; clinical outcome; cohort analysis; disease association; emergency ward; Enterococcus; female; fever; fungus isolation; hospital admission; hospital infection; human; human cell; Klebsiella pneumoniae; laboratory test; major clinical study; male; middle aged; mortality rate; nursing home; predictor variable; prescription; priority journal; prospective study; Pseudomonas aeruginosa; Taiwan; very elderly; bacteremia; bacterium; classification; community acquired infection; microbiology; mixed infection; pathology; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Bacteria; Cohort Studies; Coinfection; Community-Acquired Infections; Female; Humans; Male; Middle Aged | - |
dc.title | Clinical predictors and outcome impact of community-onset polymicrobial bloodstream infection | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.ijantimicag.2019.09.015 | - |
dc.identifier.pmid | 31560960 | - |
dc.identifier.scopus | 2-s2.0-85074434915 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85074434915 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Emergency Medicine | - |
crisitem.author.dept | Emergency Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.dept | Emergency Medicine | - |
crisitem.author.dept | Emergency Medicine-NTUH | - |
crisitem.author.dept | Emergency Medicine | - |
crisitem.author.dept | Emergency Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-4388-9984 | - |
crisitem.author.orcid | 0000-0002-5858-3013 | - |
crisitem.author.orcid | 0000-0002-1243-2463 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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