https://scholars.lib.ntu.edu.tw/handle/123456789/431133
標題: | Biocompatible and multifunctional gold nanorods for effective photothermal therapy of oral squamous cell carcinoma | 作者: | Liao, Y.-T. Liu, C.-H. Chin, Y. Chen, S.-Y. SHING-HWA LIU Hsu, Y.-C. KEVIN CHIA-WEN WU |
公開日期: | 2019 | 出版社: | Royal Society of Chemistry | 卷: | 7 | 期: | 28 | 起(迄)頁: | 4451-4460 | 來源出版物: | Journal of Materials Chemistry B | 摘要: | Herein, a cysteine-functionalized alginate was used to replace cytotoxic cetyltrimethylammonium bromide (CTAB) on gold nanorods (GNRs) by gold-thiol bonding. The characterization shows that the alginate-modified GNRs (GNR@Alg-Cys) were 137 nm in length (measured by zetasizer) with a negative surface charge (-28.4 mV). The GNR@Alg-Cys showed an intense absorption at 800 nm, indicating the potential of GNR@Alg-Cys for NIR-excited photothermal therapy (PTT). To target cancer cells, a cyclic peptide, c(RGDfK)KKK, was further modified on GNR@Alg-Cys (denoted as GNR@Alg-Cys/RGD). In vitro experiments reveal the apparently enhanced cell viability under a high dose of GNRs as well as the death of SAS-3 cell lines exposed to a single-wavelength laser (808 nm). The animal study revealed that the volume of GNR@Alg-Cys/RGD-treated laser-exposed tumor was reduced five times when compared with that in the case of the control group (PBS-treated tumor). Furthermore, the in vivo toxicity of GNR@Alg-Cys/RGD was evaluated, and no significant effect was observed on the functions of liver and kidneys after PTT. ? 2019 The Royal Society of Chemistry. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069178006&doi=10.1039%2fc9tb00574a&partnerID=40&md5=8e9161089e6d6187e6aef0751201d82e https://scholars.lib.ntu.edu.tw/handle/123456789/431133 |
ISSN: | 2050-750X | DOI: | 10.1039/c9tb00574a | SDG/關鍵字: | Amino acids; Biocompatibility; Cell culture; Cells; Gold; Nanorods; Peptides; Plasmons; Tumors; Cetyltrimethylammonium bromide; Control groups; Cyclic peptides; Gold nanorods (GNRs); Negative surface charges; Oral squamous cell carcinomata; Photothermal therapy; Single wavelength lasers; Nanoribbons |
顯示於: | 毒理學研究所 |
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