https://scholars.lib.ntu.edu.tw/handle/123456789/431153
標題: | Prepared Rehmanniae Radix oligosaccharide regulates postprandial and diabetic blood glucose in mice | 作者: | Chiu C.-Y. Hsu W.-H. Liu H.-K. SHING-HWA LIU Lin Y.-L. |
關鍵字: | Anti-diabetic activity; High-performance liquid chromatography; Oligosaccharides; PEPCK; Prepared Rehmanniae Radix; α-Glucosidase | 公開日期: | 2018 | 出版社: | Elsevier Ltd | 卷: | 41 | 起(迄)頁: | 210-215 | 來源出版物: | Journal of Functional Foods | 摘要: | Rehmanniae Radix (RR), the roots of Rehmannia glutinosa, is a popular Chinese materia medica. Both dried and prepared RR are used in Chinese prescriptions, but have totally different clinical purposes. A partially purified oligosaccharide from PRR (OPRR) was used to investigate its effect on oral starch tolerance test (OSTT) in fasted normal ICR mice, oral glucose tolerance test (OGTT) in diabetic db/db mice and gluconeogenesis in H4IIE cells. High-performance liquid chromatography (HPLC) served as a chemical analytical platform. Results showed OPRR treatment lowered postprandial glucose level and intestinal α-glucosidase activity in normal mice, and reversed glucose intolerance in diabetic db/db mice. In vitro study showed OPRR inhibited hepatic phosphoenolpyruvate carboxykinase (PEPCK) gene expressions in H4IIE cells. These results suggested that OPRR effectively decreased postprandial glucose level and intestinal α-glucosidase activity, and reversed glucose intolerance and inhibited gluconeogenesis. These findings suggest that OPRR may have a beneficial effect for diabetic hyperglycemia. ? 2017 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039445821&doi=10.1016%2fj.jff.2017.12.031&partnerID=40&md5=b4ecbd6d3c614f00c8be6610fb03ac94 https://scholars.lib.ntu.edu.tw/handle/123456789/431153 |
ISSN: | 1756-4646 | DOI: | 10.1016/j.jff.2017.12.031 |
顯示於: | 毒理學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。