https://scholars.lib.ntu.edu.tw/handle/123456789/431181
標題: | Clinical manifestations of combined methamphetamine with morphine and their effects on brain dopamine and 5-hydroxytryptamine release in mice | 作者: | SHING-HWA LIU Lin-Shiau S.-Y. Chang A.C. Lan K.-C. |
關鍵字: | 5-hydroxytryptamine; Combined abuse; Dopamine; Methamphetamine; Morphine | 公開日期: | 2015 | 出版社: | National Defense Medical Center | 卷: | 35 | 期: | 5 | 起(迄)頁: | 194-200 | 來源出版物: | Journal of Medical Sciences (Taiwan) | 摘要: | Background: Methamphetamine (MA) is often mixed with morphine by polydrug addicts, and polydrug abuse has become a serious health problem worldwide. The purpose of this study was to investigate the major signs and symptoms of combined MA and morphine abuse in the Emergency Department (ED). In addition, we used a mouse model to study their effects on the release of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the central nervous system. Materials and Methods: Seventy-two patients with combined MA and morphine abuse were collected during a 3-year period, and their medical records were reviewed. Mice were intraperitoneally administered MA (0.75 and 2.5 mg/kg/day) and morphine (5 mg/kg/day) either alone or in combination for 5 consecutive days. The mechanisms underlying the interaction between MA and morphine were explored by measuring the extracellular levels of DA and 5-HT in the shell of the nucleus accumbens using an in vivo microdialysis technique. Results: The most common manifestations of combined MA and morphine abuse included tachypnea, tachycardia, confusion, anxiety, delirium, insomnia, and diaphoresis in the ED. Of those, 25% of acute intoxication required hospitalization for intensive care. The group of mice treated with a combination of MA and morphine had higher concentrations of DA and 5-HT in the accumbens than with either drug alone. Conclusion: These findings suggest that MA pharmacologically interacts with morphine to induce characteristic signs and symptoms. Our preclinical results also implicate the involvement of increased DAergic and 5-HTergic neurotransmission among polydrug abusers with a combination of MA and morphine. ? 2015 JMS. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944739499&doi=10.4103%2f1011-4564.167740&partnerID=40&md5=b99f4e724d74a7003fbdb203b31f1b31 https://scholars.lib.ntu.edu.tw/handle/123456789/431181 |
ISSN: | 1011-4564 | DOI: | 10.4103/1011-4564.167740 | SDG/關鍵字: | dopamine; methamphetamine; morphine; serotonin; adult; anxiety; Article; clinical article; clinical feature; confusion; controlled study; delirium; diaphoresis; dopamine brain level; drug abuse; female; human; insomnia; male; microdialysis; mouse; nonhuman; serotonin release; smoking; tachycardia; tachypnea |
顯示於: | 毒理學研究所 |
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