|Title:||Unique wreath-like smooth muscle proliferation of the pulmonary vasculature in pulmonary veno-occlusive disease versus pulmonary arterial hypertension||Authors:||Lai, Ying-Ju
RICHARD PING CHENG
|Keywords:||Histopathological features; Hyperplastic muscle bundle; Pulmonary veno-occlusive disease||Issue Date:||12-Jun-2019||Source:||Journal of the Formosan Medical Association = Taiwan yi zhi||Abstract:||
Pulmonary veno-occlusive disease (PVOD) is a rare but fatal cause of pulmonary hypertension reported to be linked to mutations of eukaryotic initiation factor 2 alpha kinase 4 (EIF2AK4), also known as general control nonderepressible 2 kinase (GCN2). PVOD is difficult to diagnose and often initially misdiagnosed as other types of idiopathic pulmonary arterial hypertension (IPAH). To rapidly and correctly identify PVOD patients and explore the possible pathogenesis, we thoroughly investigated histopathological features and GCN2 protein levels in non-PAH, PVOD and PAH patients.
|Appears in Collections:||醫學系|
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