https://scholars.lib.ntu.edu.tw/handle/123456789/431445
標題: | Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations | 作者: | BIH-SHYA GAU Lien, S.-Y.; Young, L.; K Shiao, S.-P. |
關鍵字: | Air pollution; Leukemia; Meta-analysis; Meta-prediction; Methylenetetrahydrofolate reductase | 公開日期: | 2017 | 卷: | 8 | 期: | 3 | 起(迄)頁: | 4387-4398 | 來源出版物: | Oncotarget | 摘要: | The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the metapredictive techniques. The secondary objective was to examine the interactions among epigenetic risk factors (including air pollution), MTHFR polymorphisms, and the risks of developing leukemia. We completed a comprehensive search of 6 databases to find 54 studies (10,033 leukemia cases and 15,835 controls) for MTHFR 677, and 43 studies (8,868 cases and 14,301 controls) for MTHFR 1298, published from 1999 to 2014. The results revealed that, in European populations; childhood populations; children from Europe, East Asia, and America; and children with acute lymphocytic leukemia (ALL), MTHFR 677 polymorphisms (both TT and CT types together and individually) are protective, while CC wildtype was leukemogenic. In addition, MTHFR 1298 polymorphisms were protective against ALL and acute myeloid leukemia in European children, and in chronic myeloid leukemia in all adults worldwide and American adults. Air pollution played a role in the increased polymorphisms of MTHFR 677 genotypes in childhood leukemia. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/431445 | DOI: | 10.18632/oncotarget.13876 | SDG/關鍵字: | methylenetetrahydrofolate reductase (NADPH2); acute lymphoblastic leukemia; acute myeloid leukemia; age distribution; air pollution; Article; cancer risk; chronic myeloid leukemia; DNA polymorphism; East Asian; epigenetics; Europe; gene; gene mutation; genetic association; genetic linkage; genetic risk; genotype; geographic distribution; human; leukemia; leukemogenesis; MTHFR gene; population distribution; population research; risk factor; Western Hemisphere |
顯示於: | 護理學系所 |
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