|Title:||Arecoline activates latent transforming growth factor β1 via mitochondrial reactive oxygen species in buccal fibroblasts: Suppression by epigallocatechin-3-gallate||Authors:||Hsieh, Yu-Ping
|Keywords:||Areca nut chewing; EGCG; Fibroblast; Oral submucous fibrosis; TGFβ||Issue Date:||Jun-2018||Journal Volume:||117||Journal Issue:||6||Source:||Journal of the Formosan Medical Association = Taiwan yi zhi||Abstract:||
Oral submucous fibrosis (OSF) is a premalignant condition caused by the chewing of areca nut (AN). Transforming growth factor β (TGFβ) plays a central role in the pathogenesis of OSF. Connective tissue growth factor (CTGF or CCN2) and early growth response-1 (Egr-1) are important mediators in the fibrotic response to TGFβ in several fibrotic disorders including OSF. Arecoline, a major AN alkaloid, induced the synthesis of CCN2 and Egr-1 in human buccal mucosal fibroblast (BMFs). The aims of this study were to investigate whether arecoline-induced CCN2 and Egr-1 syntheses are mediated through TGFβ1 signaling and to inspect the detailed mechanisms involved.
|Appears in Collections:||臨床牙醫學研究所|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.