https://scholars.lib.ntu.edu.tw/handle/123456789/433955
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HSI-YU YU | en_US |
dc.contributor.author | Lin M.-H. | en_US |
dc.contributor.author | LIAN-YU LIN | en_US |
dc.contributor.author | CHIH-HSIEN WANG | en_US |
dc.contributor.author | NAI-HSIN CHI | en_US |
dc.contributor.author | YIH-SHARNG CHEN | en_US |
dc.creator | Yu H.-Y.;Lin M.-H.;Lin L.-Y.;Wang C.-H.;Chi N.-H.;Yih-Sharng Chen | - |
dc.date.accessioned | 2019-11-27T06:54:22Z | - |
dc.date.available | 2019-11-27T06:54:22Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044259800&doi=10.1253%2fcircj.CJ-17-1172&partnerID=40&md5=4d8c1fe20a92a6e7f5593ee5dad4923f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/433955 | - |
dc.description.abstract | Background: Asian patients on warfarin therapy usually have lower international normalized ratio (INR) intensities than those recommended by Western clinical practice guidelines. This study evaluated whether a high INR reduces the incidence of thromboembolism (TE) or bleeding events in Asian patients with high CHA 2 DS 2 -VASc scores after valve surgery. Methods and Results: Data of adult patients after valve surgery were retrieved from an integrated healthcare information system of a single hospital between 2014 and 2016. The INR was derived from the closest laboratory data before the index outpatient-clinic visit date. The endpoint of every record was determined as emergency room visit or hospitalization because of TE or bleeding event. A total of 37 TE or bleeding events were retrieved from 8,207 records; the annual incidence rate were 1.2% and 2.8% for low (0–2) and high (3–8) CHA 2 DS 2 -VASc score groups, respectively (P=0.007). The incidence rates were lowest for both groups at an INR of 1.5–2.0. High INR intensities did not reduce TE or bleeding incidence. INR >3.0 was associated with increased TE or bleeding incidence in the high-score group (6.8%/year vs. 2.0%/year, P=0.079). Conclusions: The optimal INR is 1.5–2.5 for low- or high-score Asian patients after valve surgery. INR >3.0 was associated with increased TE or bleeding incidence in the high-score group. ? 2018, Japanese Circulation Society. All rights reserved. | - |
dc.publisher | Japanese Circulation Society | - |
dc.relation.ispartof | Circulation Journal | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | anticoagulant agent; warfarin; anticoagulant agent; adult; aged; Article; bleeding; brain ischemia; CHA2DS2-VASc score; diabetes mellitus; female; health care system; heart valve surgery; hospitalization; human; hypertension; ICD-9; incidence; major clinical study; male; middle aged; risk factor; thromboembolism; xenograft; Asian continental ancestry group; bleeding; heart valve; international normalized ratio; postoperative care; procedures; retrospective study; risk assessment; standards; surgery; thromboembolism; very elderly; Aged; Aged, 80 and over; Anticoagulants; Asian Continental Ancestry Group; Female; Heart Valves; Hemorrhage; Humans; Incidence; International Normalized Ratio; Male; Middle Aged; Postoperative Care; Retrospective Studies; Risk Assessment; Thromboembolism; Warfarin | - |
dc.title | Do patients with high CHA 2 DS 2 -VASC scores need high intensity of anticoagulants after valve surgery? | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1253/circj.CJ-17-1172 | - |
dc.identifier.pmid | 29367515 | - |
dc.identifier.scopus | 2-s2.0-85044259800 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
dc.relation.pages | 1186-1194 | - |
dc.relation.journalvolume | 82 | - |
dc.relation.journalissue | 4 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Master's Program in Smart Medicine and Health Informatics (SMARTMHI) | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0001-6669-4699 | - |
crisitem.author.orcid | 0000-0001-7505-6429 | - |
crisitem.author.orcid | 0000-0003-3214-6867 | - |
crisitem.author.orcid | 0000-0003-1829-6084 | - |
crisitem.author.orcid | 0000-0003-3846-8162 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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