https://scholars.lib.ntu.edu.tw/handle/123456789/433959
Title: | Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation /631/250/127 /692/53/2422 /13 /13/21 /13/31 /45/23 article | Authors: | Liu C.-H. SHUENN-WEN KUO Ko W.-J. Tsai P.-R. Wu S.-W. Lai C.-H. CHIH-HSIEN WANG YIH-SHARNG CHEN PEI-LUNG CHEN Liu T.-T. SHU-CHIEN HUANG TZUU-SHUH JOU |
Issue Date: | 2017 | Publisher: | Nature Publishing Group | Journal Volume: | 7 | Journal Issue: | 1 | Source: | Scientific Reports | Abstract: | Patients diagnosed with acute respiratory distress syndrome are generally severely distressed and associated with high morbidity and mortality despite aggressive treatments such as extracorporeal membrane oxygenation (ECMO) support. To identify potential biomarker of predicting value for appropriate use of this intensive care resource, plasma interleukin-10 along with relevant inflammatory cytokines and immune cell populations were examined during the early and subsequent disease courses of 51 critically ill patients who received ECMO support. High interleukin-10 levels at the time of ECMO installation and during the first 6 hours after ECMO support of these patients stand as a promising biomarker associated with grave prognosis. The initial interleukin-10 level is correlated to other conventional risk evaluation scores as a predictive factor for survival, and furthermore, elevated interleukin-10 levels are also related to a delayed recovery of certain immune cell populations such as CD14+CD16+, CD14+TLR4+ monocytes, and T regulator cells. Genetically, high interleukin-10 is associated to two polymorphic nucleotides (-592 C and -819 C) at the interleukin-10 gene promoter area. Our finding provides prognostic and mechanistic information on the outcome of severely respiratory distressed patients, and potentially paves the strategy to develop new therapeutic modality based on the principles of precision medicine. ? 2017 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018182756&doi=10.1038%2fs41598-017-01225-1&partnerID=40&md5=6912a20ae6d3666ad92a38d1eddcbe2e https://scholars.lib.ntu.edu.tw/handle/123456789/433959 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-01225-1 | SDG/Keyword: | IL10 protein, human; interleukin 10; adult; adult respiratory distress syndrome; aged; blood; critical illness; extracorporeal oxygenation; female; genetics; human; male; metabolism; middle aged; procedures; prognosis; promoter region; severity of illness index; survival analysis; Adult; Aged; Critical Illness; Extracorporeal Membrane Oxygenation; Female; Humans; Interleukin-10; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Respiratory Distress Syndrome, Adult; Severity of Illness Index; Survival Analysis |
Appears in Collections: | 醫學系 |
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