https://scholars.lib.ntu.edu.tw/handle/123456789/434515
Title: | Sonographic lenticulostriate vasculopathy in infancy with tic and other neuropsychiatric disorders developed after 7 to 9 years of follow-up | Authors: | Wang H.-S. MENG-FAI KUO |
Issue Date: | 2003 | Publisher: | Elsevier | Journal Volume: | 25 | Journal Issue: | SUPPL. 1 | Start page/Pages: | S43-S47 | Source: | Brain and Development | Abstract: | On gray-scale transfontanel sonography, the small arteries supplying the basal ganglia are indistinct from the brain parenchyma in normal infants. Bright linear 'branched candlestick' stripes in these regions, suggesting sonographic lenticulostriate vasculopathy, were reported in more than 200 infants in the English literature; including 34 our own patients. To identify its long-term outcome, a prospective study was accomplished on our 34 infants with sonographic lenticulostriate vasculopathy which included 13 cryptogenic cases and 21 with distinct etiologies. At the age of 7 to 9 years in the cryptogenic group, 7 in 13 patients developed tics, attention deficits, hyperactivity, and/or obsession/compulsion; while in the symptomatic group only 2 of 21 patientd had tics. The rate of mortality (33% vs. 0%) developmental delay (24% vs. 8%) mental retardation (24% vs. 0%) and neurologic deficits (29% vs. 0%) were significantly higher in the symptomatic group than the cryptogenic group. Comparatively, the occurrence rate of attention deficit-hyperactivity disorder (10% vs. 54%) tics (10% vs. 38%) and obsessive-compulsive disorder (5% vs. 13%) were significantly lower in the symptomatic group than the cryptogenic group. The rates of these neuropsychiatric disorders were 10% in the symptomatic group and 54% in the cryptogenic group. We concluded that idiopathic sonographic lenticulostriate vasculopathy in infancy may predict development of neuropsychiatric disorders later in childhood. ? 2003 Elsevier Science B. V. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-10644279841&doi=10.1016%2fS0387-7604%2803%2990008-8&partnerID=40&md5=60d049206de9771840780010624e07a4 https://scholars.lib.ntu.edu.tw/handle/123456789/434515 |
ISSN: | 0387-7604 | DOI: | 10.1016/S0387-7604(03)90008-8 | SDG/Keyword: | age distribution; attention deficit disorder; cerebrovascular disease; child; childhood mortality; clinical article; conference paper; controlled study; developmental disorder; disease association; female; follow up; growth retardation; human; infancy; infant disease; linear system; male; mental deficiency; neurologic disease; obsessive compulsive disorder; psychopathy; school child; sonographic lenticulostriate vasculopathy; statistical significance; symptomatology; tic; article; attention deficit disorder; basal ganglion; basal ganglion hemorrhage; computer assisted tomography; echography; middle cerebral artery; nuclear magnetic resonance imaging; obsessive compulsive disorder; onset age; pathology; pathophysiology; preschool child; prospective study; tic; time; vascularization; Age of Onset; Attention Deficit Disorder with Hyperactivity; Basal Ganglia; Basal Ganglia Cerebrovascular Disease; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Cerebral Artery; Obsessive-Compulsive Disorder; Prospective Studies; Tic Disorders; Time; Tomography, X-Ray Computed |
Appears in Collections: | 醫學系 |
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