https://scholars.lib.ntu.edu.tw/handle/123456789/434522
Title: | Pyridoxal phosphate-responsive epilepsy with resistance to pyridoxine | Authors: | MENG-FAI KUO Wang H.-S. |
Issue Date: | 2002 | Journal Volume: | 26 | Journal Issue: | 2 | Start page/Pages: | 146-147 | Source: | Pediatric Neurology | Abstract: | We present a female infant with seizures responsive to pyridoxal phosphate but that are resistant to pyridoxine. The mechanism by which pyridoxal phosphate controls seizures in this patient is unknown. Her seizures are perhaps not solely caused by pyridoxal phosphate deficiency. It is suggested that in addition to glutamic acid decarboxylase abnormality, the path from the absorption, transportation, phosphorylation, and oxidation of pyridoxine to pyridoxal phosphate in this patient might be defective. It should be considered whether pyridoxal phosphate can be the drug of choice instead of pyridoxine in treating patients suspected of pyridoxine-dependent epilepsy to reduce failure rate and further delay in seizure control. Copyright ? 2002 Elsevier Science Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036191050&doi=10.1016%2fS0887-8994%2801%2900357-5&partnerID=40&md5=502ba83e4540541c2c4827bfc11a6916 https://scholars.lib.ntu.edu.tw/handle/123456789/434522 |
ISSN: | 0887-8994 | DOI: | 10.1016/S0887-8994(01)00357-5 | SDG/Keyword: | glutamate decarboxylase; phenobarbital; pyridoxal 5 phosphate; pyridoxine; vigabatrin; article; case report; drug absorption; drug mechanism; drug metabolism; drug oxidation; drug transport; epilepsy; female; human; newborn; phosphorylation; priority journal; pyridoxine deficiency; seizure; Administration, Oral; Electroencephalography; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Infusions, Intravenous; Pyridoxal Phosphate; Pyridoxine; Spasms, Infantile; Treatment Failure |
Appears in Collections: | 醫學系 |
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